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Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles

The contribution of the complement system to non-specific host defence and maintenance of homeostasis is well appreciated. Many particulate systems trigger complement activation but the underlying mechanisms are still poorly understood. Activation of the complement cascade could lead to particle ops...

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Detalles Bibliográficos
Autores principales: Moghimi, S. Moein, Haroon, Hajira B., Yaghmur, Anan, Simberg, Dmitri, Trohopoulos, Panagiotis N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200249/
https://www.ncbi.nlm.nih.gov/pubmed/36152807
http://dx.doi.org/10.1016/j.jconrel.2022.09.039
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author Moghimi, S. Moein
Haroon, Hajira B.
Yaghmur, Anan
Simberg, Dmitri
Trohopoulos, Panagiotis N.
author_facet Moghimi, S. Moein
Haroon, Hajira B.
Yaghmur, Anan
Simberg, Dmitri
Trohopoulos, Panagiotis N.
author_sort Moghimi, S. Moein
collection PubMed
description The contribution of the complement system to non-specific host defence and maintenance of homeostasis is well appreciated. Many particulate systems trigger complement activation but the underlying mechanisms are still poorly understood. Activation of the complement cascade could lead to particle opsonisation by the cleavage products of the third complement protein and might promote inflammatory reactions. Antibody binding in a controlled manner and/or sensing of particles by the complement pattern-recognition molecules such as C1q and mannose-binding lectin can trigger complement activation. Particle curvature and spacing arrangement/periodicity of surface functional groups/ligands are two important parameters that modulate complement responses through multivalent engagement with and conformational regulation of surface-bound antibodies and complement pattern-recognition molecules. Thus, a better fundamental understanding of nanometer- and angstrom-scale parameters that modulate particle interaction with antibodies and complement proteins could portend new possibilities for engineering of particulate drug carriers and biomedical platforms with tuneable complement responses and is discussed here.
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spelling pubmed-102002492023-11-01 Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles Moghimi, S. Moein Haroon, Hajira B. Yaghmur, Anan Simberg, Dmitri Trohopoulos, Panagiotis N. J Control Release Article The contribution of the complement system to non-specific host defence and maintenance of homeostasis is well appreciated. Many particulate systems trigger complement activation but the underlying mechanisms are still poorly understood. Activation of the complement cascade could lead to particle opsonisation by the cleavage products of the third complement protein and might promote inflammatory reactions. Antibody binding in a controlled manner and/or sensing of particles by the complement pattern-recognition molecules such as C1q and mannose-binding lectin can trigger complement activation. Particle curvature and spacing arrangement/periodicity of surface functional groups/ligands are two important parameters that modulate complement responses through multivalent engagement with and conformational regulation of surface-bound antibodies and complement pattern-recognition molecules. Thus, a better fundamental understanding of nanometer- and angstrom-scale parameters that modulate particle interaction with antibodies and complement proteins could portend new possibilities for engineering of particulate drug carriers and biomedical platforms with tuneable complement responses and is discussed here. 2022-11 2022-09-27 /pmc/articles/PMC10200249/ /pubmed/36152807 http://dx.doi.org/10.1016/j.jconrel.2022.09.039 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Moghimi, S. Moein
Haroon, Hajira B.
Yaghmur, Anan
Simberg, Dmitri
Trohopoulos, Panagiotis N.
Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title_full Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title_fullStr Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title_full_unstemmed Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title_short Nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
title_sort nanometer- and angstrom-scale characteristics that modulate complement responses to nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200249/
https://www.ncbi.nlm.nih.gov/pubmed/36152807
http://dx.doi.org/10.1016/j.jconrel.2022.09.039
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