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A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance

Amyloidosis of the gastrointestinal (GI) tract is caused by the deposition of fibrils made of serum proteins into extracellular spaces. It is an uncommon disease with a poor prognosis, requiring prompt diagnosis and treatment. Treatment for amyloid light chain (AL)-type amyloidosis involves supporti...

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Autores principales: Singh, Sarah, Gopireddy, Guru, Naum, Scott, Iannetti, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200344/
https://www.ncbi.nlm.nih.gov/pubmed/37220448
http://dx.doi.org/10.7759/cureus.37953
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author Singh, Sarah
Gopireddy, Guru
Naum, Scott
Iannetti, Michael P
author_facet Singh, Sarah
Gopireddy, Guru
Naum, Scott
Iannetti, Michael P
author_sort Singh, Sarah
collection PubMed
description Amyloidosis of the gastrointestinal (GI) tract is caused by the deposition of fibrils made of serum proteins into extracellular spaces. It is an uncommon disease with a poor prognosis, requiring prompt diagnosis and treatment. Treatment for amyloid light chain (AL)-type amyloidosis involves supportive care as well as addressing any underlying plasma cell dyscrasias. We present the case of a 64-year-old female diagnosed with AL-type GI amyloidosis with associated monoclonal gammopathy of undetermined significance. Unfortunately, the treatment was initiated nine months after the initial presentation, and she died one month later. Awareness of GI amyloidosis may allow for faster diagnosis and treatment in future patients.
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spelling pubmed-102003442023-05-22 A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance Singh, Sarah Gopireddy, Guru Naum, Scott Iannetti, Michael P Cureus Gastroenterology Amyloidosis of the gastrointestinal (GI) tract is caused by the deposition of fibrils made of serum proteins into extracellular spaces. It is an uncommon disease with a poor prognosis, requiring prompt diagnosis and treatment. Treatment for amyloid light chain (AL)-type amyloidosis involves supportive care as well as addressing any underlying plasma cell dyscrasias. We present the case of a 64-year-old female diagnosed with AL-type GI amyloidosis with associated monoclonal gammopathy of undetermined significance. Unfortunately, the treatment was initiated nine months after the initial presentation, and she died one month later. Awareness of GI amyloidosis may allow for faster diagnosis and treatment in future patients. Cureus 2023-04-21 /pmc/articles/PMC10200344/ /pubmed/37220448 http://dx.doi.org/10.7759/cureus.37953 Text en Copyright © 2023, Singh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Singh, Sarah
Gopireddy, Guru
Naum, Scott
Iannetti, Michael P
A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title_full A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title_fullStr A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title_full_unstemmed A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title_short A Rare Case of Gastrointestinal Amyloidosis Due to Monoclonal Gammopathy of Undetermined Significance
title_sort rare case of gastrointestinal amyloidosis due to monoclonal gammopathy of undetermined significance
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200344/
https://www.ncbi.nlm.nih.gov/pubmed/37220448
http://dx.doi.org/10.7759/cureus.37953
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