A selectivity filter in the ER membrane protein complex limits protein misinsertion at the ER

Tail-anchored (TA) proteins play essential roles in mammalian cells, and their accurate localization is critical for proteostasis. Biophysical similarities lead to mistargeting of mitochondrial TA proteins to the ER, where they are delivered to the insertase, the ER membrane protein complex (EMC). L...

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Detalles Bibliográficos
Autores principales: Pleiner, Tino, Hazu, Masami, Pinton Tomaleri, Giovani, Nguyen, Vy N., Januszyk, Kurt, Voorhees, Rebecca M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200711/
https://www.ncbi.nlm.nih.gov/pubmed/37199759
http://dx.doi.org/10.1083/jcb.202212007

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