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Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review

BACKGROUND: C-terminal Agrin Fragment (CAF) has emerged as a potent biomarker for identifying sarcopenia. However, the effect of interventions on CAF concentration and the association of CAF with sarcopenia components are unclear. OBJECTIVE: To review the association between CAF concentration and mu...

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Autores principales: Kumar, Prabal, Nayak, Kusumakshi, Umakanth, Shashikiran, Girish, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200783/
https://www.ncbi.nlm.nih.gov/pubmed/36977974
http://dx.doi.org/10.1007/s40520-023-02396-w
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author Kumar, Prabal
Nayak, Kusumakshi
Umakanth, Shashikiran
Girish, N.
author_facet Kumar, Prabal
Nayak, Kusumakshi
Umakanth, Shashikiran
Girish, N.
author_sort Kumar, Prabal
collection PubMed
description BACKGROUND: C-terminal Agrin Fragment (CAF) has emerged as a potent biomarker for identifying sarcopenia. However, the effect of interventions on CAF concentration and the association of CAF with sarcopenia components are unclear. OBJECTIVE: To review the association between CAF concentration and muscle mass, muscle strength, and physical performance among individuals with primary and secondary sarcopenia and to synthesize the effect of interventions on the change in the level of CAF concentration. METHODS: A systematic literature search was conducted in six electronic databases, and studies were included if they met the selection criteria decided a priori. The data extraction sheet was prepared, validated, and extracted relevant data. RESULTS: A total of 5,158 records were found, of which 16 were included. Among studies conducted on individuals with primary sarcopenia, muscle mass was significantly associated with CAF levels, followed by hand grip strength (HGS) and physical performance, with more consistent findings in males. While in secondary sarcopenics, the strongest association was found for HGS and CAF levels, followed by physical performance and muscle mass. CAF concentration was reduced in trials that used functional, dual task, and power training, whereas resistance training and physical activity raised CAF levels. Hormonal therapy did not affect serum CAF concentration. CONCLUSION(S): The association between CAF and sarcopenic assessment parameters varies in primary and secondary sarcopenics. The findings would help practitioners and researchers choose the best training mode/parameters/exercises to reduce CAF levels and, eventually, manage sarcopenia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-023-02396-w.
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spelling pubmed-102007832023-05-23 Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review Kumar, Prabal Nayak, Kusumakshi Umakanth, Shashikiran Girish, N. Aging Clin Exp Res Review BACKGROUND: C-terminal Agrin Fragment (CAF) has emerged as a potent biomarker for identifying sarcopenia. However, the effect of interventions on CAF concentration and the association of CAF with sarcopenia components are unclear. OBJECTIVE: To review the association between CAF concentration and muscle mass, muscle strength, and physical performance among individuals with primary and secondary sarcopenia and to synthesize the effect of interventions on the change in the level of CAF concentration. METHODS: A systematic literature search was conducted in six electronic databases, and studies were included if they met the selection criteria decided a priori. The data extraction sheet was prepared, validated, and extracted relevant data. RESULTS: A total of 5,158 records were found, of which 16 were included. Among studies conducted on individuals with primary sarcopenia, muscle mass was significantly associated with CAF levels, followed by hand grip strength (HGS) and physical performance, with more consistent findings in males. While in secondary sarcopenics, the strongest association was found for HGS and CAF levels, followed by physical performance and muscle mass. CAF concentration was reduced in trials that used functional, dual task, and power training, whereas resistance training and physical activity raised CAF levels. Hormonal therapy did not affect serum CAF concentration. CONCLUSION(S): The association between CAF and sarcopenic assessment parameters varies in primary and secondary sarcopenics. The findings would help practitioners and researchers choose the best training mode/parameters/exercises to reduce CAF levels and, eventually, manage sarcopenia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-023-02396-w. Springer International Publishing 2023-03-28 2023 /pmc/articles/PMC10200783/ /pubmed/36977974 http://dx.doi.org/10.1007/s40520-023-02396-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Kumar, Prabal
Nayak, Kusumakshi
Umakanth, Shashikiran
Girish, N.
Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title_full Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title_fullStr Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title_full_unstemmed Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title_short Effect of targeted intervention on C-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
title_sort effect of targeted intervention on c-terminal agrin fragment and its association with the components of sarcopenia: a scoping review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200783/
https://www.ncbi.nlm.nih.gov/pubmed/36977974
http://dx.doi.org/10.1007/s40520-023-02396-w
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