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Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil
The emergence of immune checkpoint inhibitors (ICIs) has significantly prolonged the survival time of cancer patients. However, it may also lead to various immune-related adverse events (irAEs), including Guillain–Barré syndrome (GBS), a rare type of irAE. Most GBS patients can recover spontaneously...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200921/ https://www.ncbi.nlm.nih.gov/pubmed/37223099 http://dx.doi.org/10.3389/fimmu.2023.1132692 |
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author | Ding, Mengge Deng, Chao Liu, Xianling Jiang, Shun Gao, Yuan Fan, Dan Zhou, Yiguang He, Jiangbo Liu, Chaoyuan |
author_facet | Ding, Mengge Deng, Chao Liu, Xianling Jiang, Shun Gao, Yuan Fan, Dan Zhou, Yiguang He, Jiangbo Liu, Chaoyuan |
author_sort | Ding, Mengge |
collection | PubMed |
description | The emergence of immune checkpoint inhibitors (ICIs) has significantly prolonged the survival time of cancer patients. However, it may also lead to various immune-related adverse events (irAEs), including Guillain–Barré syndrome (GBS), a rare type of irAE. Most GBS patients can recover spontaneously due to the self-limited nature of the disease, but severe cases can result in respiratory failure or even death. Here we report a rare case of GBS occurring in a 58-year-old male patient with non-small cell lung cancer (NSCLC) who developed muscle weakness and numbness of the extremities during chemotherapy combined with KN046, a PD-L1/CTLA-4 bispecific antibody. Despite receiving methylprednisolone and γ-globulin, the patient’s symptoms did not improve. However, there was significant improvement after treatment with mycophenolate mofetil (MM) capsules, which is not a routine regimen for GBS. To the best of our knowledge, this is the first reported case of ICIs-induced GBS that responded well to mycophenolate mofetil instead of methylprednisolone or γ-globulin. Thus, it provides a new treatment option for patients with ICIs-induced GBS. |
format | Online Article Text |
id | pubmed-10200921 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102009212023-05-23 Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil Ding, Mengge Deng, Chao Liu, Xianling Jiang, Shun Gao, Yuan Fan, Dan Zhou, Yiguang He, Jiangbo Liu, Chaoyuan Front Immunol Immunology The emergence of immune checkpoint inhibitors (ICIs) has significantly prolonged the survival time of cancer patients. However, it may also lead to various immune-related adverse events (irAEs), including Guillain–Barré syndrome (GBS), a rare type of irAE. Most GBS patients can recover spontaneously due to the self-limited nature of the disease, but severe cases can result in respiratory failure or even death. Here we report a rare case of GBS occurring in a 58-year-old male patient with non-small cell lung cancer (NSCLC) who developed muscle weakness and numbness of the extremities during chemotherapy combined with KN046, a PD-L1/CTLA-4 bispecific antibody. Despite receiving methylprednisolone and γ-globulin, the patient’s symptoms did not improve. However, there was significant improvement after treatment with mycophenolate mofetil (MM) capsules, which is not a routine regimen for GBS. To the best of our knowledge, this is the first reported case of ICIs-induced GBS that responded well to mycophenolate mofetil instead of methylprednisolone or γ-globulin. Thus, it provides a new treatment option for patients with ICIs-induced GBS. Frontiers Media S.A. 2023-05-08 /pmc/articles/PMC10200921/ /pubmed/37223099 http://dx.doi.org/10.3389/fimmu.2023.1132692 Text en Copyright © 2023 Ding, Deng, Liu, Jiang, Gao, Fan, Zhou, He and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ding, Mengge Deng, Chao Liu, Xianling Jiang, Shun Gao, Yuan Fan, Dan Zhou, Yiguang He, Jiangbo Liu, Chaoyuan Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title | Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title_full | Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title_fullStr | Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title_full_unstemmed | Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title_short | Case Report: ICIs-induced Guillain–Barré syndrome recovered from mycophenolate mofetil |
title_sort | case report: icis-induced guillain–barré syndrome recovered from mycophenolate mofetil |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200921/ https://www.ncbi.nlm.nih.gov/pubmed/37223099 http://dx.doi.org/10.3389/fimmu.2023.1132692 |
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