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A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk

Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adult...

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Autores principales: Deer, LillyBelle K., Su, Chen, Thwaites, Natalie A., Davis, Elysia Poggi, Doom, Jenalee R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200937/
https://www.ncbi.nlm.nih.gov/pubmed/37223037
http://dx.doi.org/10.3389/fendo.2023.1111474
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author Deer, LillyBelle K.
Su, Chen
Thwaites, Natalie A.
Davis, Elysia Poggi
Doom, Jenalee R.
author_facet Deer, LillyBelle K.
Su, Chen
Thwaites, Natalie A.
Davis, Elysia Poggi
Doom, Jenalee R.
author_sort Deer, LillyBelle K.
collection PubMed
description Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adulthood, but little is known about relations between prenatal stress-responsive hormones and early precursors of CVD, such as cardiometabolic risk and health behaviors. The current review presents a theoretical model of the relation between prenatal stress-responsive hormones and adult CVD through cardiometabolic risk markers (e.g., rapid catch-up growth, high BMI/adiposity, high blood pressure, and altered blood glucose, lipids, and metabolic hormones) and health behaviors (e.g., substance use, poor sleep, poor diet and eating behaviors, and low physical activity levels). Emerging evidence in human and non-human animal literatures suggest that altered stress-responsive hormones during gestation predict higher cardiometabolic risk and poorer health behaviors in offspring. This review additionally highlights limitations of the current literature (e.g., lack of racial/ethnic diversity, lack of examination of sex differences), and discusses future directions for this promising area of research.
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spelling pubmed-102009372023-05-23 A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk Deer, LillyBelle K. Su, Chen Thwaites, Natalie A. Davis, Elysia Poggi Doom, Jenalee R. Front Endocrinol (Lausanne) Endocrinology Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adulthood, but little is known about relations between prenatal stress-responsive hormones and early precursors of CVD, such as cardiometabolic risk and health behaviors. The current review presents a theoretical model of the relation between prenatal stress-responsive hormones and adult CVD through cardiometabolic risk markers (e.g., rapid catch-up growth, high BMI/adiposity, high blood pressure, and altered blood glucose, lipids, and metabolic hormones) and health behaviors (e.g., substance use, poor sleep, poor diet and eating behaviors, and low physical activity levels). Emerging evidence in human and non-human animal literatures suggest that altered stress-responsive hormones during gestation predict higher cardiometabolic risk and poorer health behaviors in offspring. This review additionally highlights limitations of the current literature (e.g., lack of racial/ethnic diversity, lack of examination of sex differences), and discusses future directions for this promising area of research. Frontiers Media S.A. 2023-05-08 /pmc/articles/PMC10200937/ /pubmed/37223037 http://dx.doi.org/10.3389/fendo.2023.1111474 Text en Copyright © 2023 Deer, Su, Thwaites, Davis and Doom https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Deer, LillyBelle K.
Su, Chen
Thwaites, Natalie A.
Davis, Elysia Poggi
Doom, Jenalee R.
A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title_full A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title_fullStr A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title_full_unstemmed A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title_short A framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
title_sort framework for testing pathways from prenatal stress-responsive hormones to cardiovascular disease risk
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200937/
https://www.ncbi.nlm.nih.gov/pubmed/37223037
http://dx.doi.org/10.3389/fendo.2023.1111474
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