Cargando…

Evaluation of efficacy and safety of glucokinase activators—a systematic review and meta-analysis

AIMS: Glucokinase activators (GKAs) promote the activity of glucokinase (GK) and is under development for the treatment of diabetes. The efficacy and safety of GKAs require evaluation. METHODS: This meta-analysis included randomized controlled trials (RCTs) with a duration of at least 12 weeks condu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Wenjia, Wu, Han, Cai, Xiaoling, Lin, Chu, Jiao, Ruoyang, Ji, Linong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200948/ https://www.ncbi.nlm.nih.gov/pubmed/37223016 http://dx.doi.org/10.3389/fendo.2023.1175198

Ejemplares similares

The Body Weight Alteration and Incidence of Neoplasm in Patients With Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials
por: Lin, Chu, et al.
Publicado: (2020)

The association between metabolic parameters and evening chronotype and social jetlag in non-shift workers: A meta-analysis
por: Zhang, Rui, et al.
Publicado: (2022)

Efficacy and Safety of Initial Combination Therapy in Treatment-Naïve Type 2 Diabetes Patients: A Systematic Review and Meta-analysis
por: Cai, Xiaoling, et al.
Publicado: (2018)

The Urinary Glucose Excretion by Sodium–Glucose Cotransporter 2 Inhibitor in Patients With Different Levels of Renal Function: A Systematic Review and Meta-Analysis
por: Hu, Suiyuan, et al.
Publicado: (2022)

The Effect of Physical Activity on Glycemic Variability in Patients With Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
por: Zhu, Xingyun, et al.
Publicado: (2021)

Disparities in efficacy and safety of sodium-glucose cotransporter 2 inhibitor among patients with different extents of renal dysfunction: A systematic review and meta-analysis of randomized controlled trials
por: Hu, Suiyuan, et al.
Publicado: (2022)

Meta‐analysis and critical review on the efficacy and safety of alpha‐glucosidase inhibitors in Asian and non‐Asian populations
por: Gao, Xueying, et al.
Publicado: (2017)

Non-Insulin Antidiabetes Treatment in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis
por: Cai, Xiaoling, et al.
Publicado: (2021)

Glucokinase regulatory protein: a balancing act between glucose and lipid metabolism in NAFLD
por: Zhang, Ziqi, et al.
Publicado: (2023)

Baseline Body Mass Index and the Efficacy of Hypoglycemic Treatment in Type 2 Diabetes: A Meta-Analysis
por: Cai, Xiaoling, et al.
Publicado: (2016)

Reduction of C-reactive protein, low-density lipoprotein cholesterol, and its relationship with cardiovascular events of different lipid-lowering therapies: A systematic review and meta-analysis of randomized controlled trials
por: Yang, Wenjia, et al.
Publicado: (2022)

Glucokinase Deficit Prevalence in Women With Diabetes in Pregnancy: A Matter of Screening Selection
por: Bitterman, Olimpia, et al.
Publicado: (2020)

Age, sex, disease severity, and disease duration difference in placebo response: implications from a meta-analysis of diabetes mellitus
por: Lin, Chu, et al.
Publicado: (2020)

Trends in baseline HbA1c and body-mass index in randomised placebo-controlled trials of type 2 diabetes from 1987 to 2022: a systematic review and meta-analysis
por: Hu, Suiyuan, et al.
Publicado: (2023)

Case Report: Hypoglycemia Due to a Novel Activating Glucokinase Variant in an Adult – a Molecular Approach
por: Koneshamoorthy, Anojian, et al.
Publicado: (2022)

Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges
por: Timsit, José, et al.
Publicado: (2022)

SGLT2 inhibitors and lower limb complications: an updated meta‐analysis
por: Lin, Chu, et al.
Publicado: (2021)

The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A meta-analysis
por: Gao, Qian, et al.
Publicado: (2021)

The efficacy and safety of quinagolide in hyperprolactinemia treatment: A systematic review and meta-analysis
por: Zeng, Yanyang, et al.
Publicado: (2023)

Correction to: SGLT2 inhibitors and lower limb complications: an updated meta-analysis
por: Lin, Chu, et al.
Publicado: (2021)

The efficacy and safety of glucokinase activators for the treatment of type-2 diabetes mellitus: A protocol for systematic review and meta-analysis
por: Gao, Qian, et al.
Publicado: (2021)

Reducing Glucokinase Activity to Enhance Insulin Secretion: A Counterintuitive Theory to Preserve Cellular Function and Glucose Homeostasis
por: Whitticar, Nicholas B., et al.
Publicado: (2020)

Association Between Indices of Body Composition and Metabolically Unhealthy Phenotype in China: A Cross-Sectional Study
por: Lv, Fang, et al.
Publicado: (2022)

Phenotypic and Genetic Heterogeneity in a Thai Glucokinase MODY Family Reveals the Complexity of Young-Onset Diabetes
por: Thewjitcharoen, Yotsapon, et al.
Publicado: (2021)

Functional Characterization of a Novel Heterozygous Mutation in the Glucokinase Gene That Causes MODY2 in Chinese Pedigrees
por: Jiang, Feng, et al.
Publicado: (2021)

Efficacy and Safety of intravenous monoclonal antibodies in patients with moderate-to-severe active Graves’ophthalmopathy: a systematic review and meta-analysis
por: Hu, Yu, et al.
Publicado: (2023)

Efficacy and Safety of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
por: Zhu, Yuan, et al.
Publicado: (2021)

No disparity of the efficacy and all‐cause mortality between Asian and non‐Asian type 2 diabetes patients with sodium–glucose cotransporter 2 inhibitors treatment: A meta‐analysis
por: Cai, Xiaoling, et al.
Publicado: (2017)

Efficacy and Safety of Empagliflozin on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
por: Zhang, Yuyuan, et al.
Publicado: (2022)

COVID-19 Vaccination in Patients With Malignancy; A Systematic Review and Meta-Analysis of the Efficacy and Safety
por: Javadinia, Seyed Alireza, et al.
Publicado: (2022)

The efficacy and safety of evogliptin for type 2 diabetes mellitus: A systematic review and meta-analysis
por: Tang, Qizhi, et al.
Publicado: (2022)

Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
por: Yang, Wenjia, et al.
Publicado: (2016)

Comparative efficacy and safety of glucose-lowering drugs in children and adolescents with type 2 diabetes: A systematic review and network meta-analysis
por: Wu, Sijia, et al.
Publicado: (2022)

Do East Asians With Normal Glucose Tolerance Have Worse β-Cell Function? A Meta-Analysis of Epidemiological Studies
por: Li, Li, et al.
Publicado: (2021)

Efficacy and Safety of Tripterygium Glycoside in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis Based on the Duration of Medication
por: Li, Yizhen, et al.
Publicado: (2021)

Serum Ratio of Free Triiodothyronine to Thyroid-Stimulating Hormone: A Novel Index for Distinguishing Graves’ Disease From Autoimmune Thyroiditis
por: Wu, Zhiyong, et al.
Publicado: (2021)

Efficacy and Safety of Eldecalcitol for Osteoporosis: A Meta-Analysis of Randomized Controlled Trials
por: Liu, Hongyan, et al.
Publicado: (2022)

Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein
por: Jin, Ling, et al.
Publicado: (2015)

Effect of Hemoglobin A1c Reduction or Weight Reduction on Blood Pressure in Glucagon‐Like Peptide‐1 Receptor Agonist and Sodium‐Glucose Cotransporter‐2 Inhibitor Treatment in Type 2 Diabetes Mellitus: A Meta‐Analysis
por: Hu, Mengdie, et al.
Publicado: (2020)

The Biological Disease-Modifying Antirheumatic Drugs and the Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis
por: Hu, Suiyuan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s53olcb4to9ieggmqjmb9cgskg