A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models

Bacterial lipopolysaccharides (LPS) are potent innate immunostimulants targeting the Toll-like receptor 4 (TLR4), an attractive and validated target for immunostimulation in cancer therapy. Although LPS possess anti-tumor activity, toxicity issues prevent their systemic administration at effective d...

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Detalles Bibliográficos
Autores principales: Chettab, Kamel, Fitzsimmons, Chantel, Novikov, Alexey, Denis, Morgane, Phelip, Capucine, Mathé, Doriane, Choffour, Pierre Antoine, Beaumel, Sabine, Fourmaux, Eric, Norca, Patrick, Kryza, David, Evesque, Anne, Jordheim, Lars Petter, Perrial, Emeline, Matera, Eva-Laure, Caroff, Martine, Kerzerho, Jerome, Dumontet, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200957/
https://www.ncbi.nlm.nih.gov/pubmed/37223101
http://dx.doi.org/10.3389/fimmu.2023.1066402

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