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Stimulating β-adrenergic receptors promotes synaptic potentiation by switching CaMKII movement from LTD to LTP mode

Learning, memory, and cognition are thought to require synaptic plasticity, specifically including hippocampal long-term potentiation and depression (LTP and LTD). LTP versus LTD is induced by high-frequency stimulation versus low-frequency, but stimulating β-adrenergic receptors (βARs) enables LTP...

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Detalles Bibliográficos
Autores principales: Larsen, Matthew E., Buonarati, Olivia R., Qian, Hai, Hell, Johannes W., Bayer, K. Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200978/
https://www.ncbi.nlm.nih.gov/pubmed/37061000
http://dx.doi.org/10.1016/j.jbc.2023.104706