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Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy
Intrahepatic cholangiocarcinoma is an aggressive, often fatal, malignancy that arises from the bile ducts. As it often presents with metastatic disease, surgery has limited utility. However, in some cases, neoadjuvant chemotherapy has provided the necessary reduction in tumor burden to allow for ade...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association of Hepato-Biliary-Pancreatic Surgery
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201062/ https://www.ncbi.nlm.nih.gov/pubmed/36823963 http://dx.doi.org/10.14701/ahbps.22-110 |
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author | Ghio, Michael Vijay, Adarsh |
author_facet | Ghio, Michael Vijay, Adarsh |
author_sort | Ghio, Michael |
collection | PubMed |
description | Intrahepatic cholangiocarcinoma is an aggressive, often fatal, malignancy that arises from the bile ducts. As it often presents with metastatic disease, surgery has limited utility. However, in some cases, neoadjuvant chemotherapy has provided the necessary reduction in tumor burden to allow for adequate resection. Consequently, new advances in neoadjuvant chemoradiation and targeted therapy are of interest with numerous case reports and small series published routinely; it is challenging to present a large case series or study given the overall rare frequency with which this malignancy is seen. Herein, we aim to summarize the newest advances in both neoadjuvant chemotherapy and targeted immunotherapy. |
format | Online Article Text |
id | pubmed-10201062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Korean Association of Hepato-Biliary-Pancreatic Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-102010622023-05-23 Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy Ghio, Michael Vijay, Adarsh Ann Hepatobiliary Pancreat Surg Review Article Intrahepatic cholangiocarcinoma is an aggressive, often fatal, malignancy that arises from the bile ducts. As it often presents with metastatic disease, surgery has limited utility. However, in some cases, neoadjuvant chemotherapy has provided the necessary reduction in tumor burden to allow for adequate resection. Consequently, new advances in neoadjuvant chemoradiation and targeted therapy are of interest with numerous case reports and small series published routinely; it is challenging to present a large case series or study given the overall rare frequency with which this malignancy is seen. Herein, we aim to summarize the newest advances in both neoadjuvant chemotherapy and targeted immunotherapy. The Korean Association of Hepato-Biliary-Pancreatic Surgery 2023-05-31 2023-02-24 /pmc/articles/PMC10201062/ /pubmed/36823963 http://dx.doi.org/10.14701/ahbps.22-110 Text en Copyright © 2023 by The Korean Association of Hepato-Biliary-Pancreatic Surgery https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ghio, Michael Vijay, Adarsh Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title | Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title_full | Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title_fullStr | Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title_full_unstemmed | Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title_short | Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy |
title_sort | intrahepatic cholangiocarcinoma: evolving role of neoadjuvant and targeted therapy |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201062/ https://www.ncbi.nlm.nih.gov/pubmed/36823963 http://dx.doi.org/10.14701/ahbps.22-110 |
work_keys_str_mv | AT ghiomichael intrahepaticcholangiocarcinomaevolvingroleofneoadjuvantandtargetedtherapy AT vijayadarsh intrahepaticcholangiocarcinomaevolvingroleofneoadjuvantandtargetedtherapy |