Application of particle swarm optimization to understand the mechanism of action of allosteric inhibitors of the enzyme HSD17β13

Understanding a drug candidate’s mechanism of action is crucial for its further development. However, kinetic schemes are often complex and multi-parametric, especially for proteins in oligomerization equilibria. Here, we demonstrate the use of particle swarm optimization (PSO) as a method to select...

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Detalles Bibliográficos
Autores principales: Ford, Amy, Breitgoff, Frauke, Pasquini, Miriam, MacKenzie, Amanda, McElroy, Stuart, Baker, Steve, Abrusci, Patrizia, Varzandeh, Simon, Bird, Louise, Gavard, Angeline, Damerell, David, Redhead, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201303/
https://www.ncbi.nlm.nih.gov/pubmed/37223265
http://dx.doi.org/10.1016/j.patter.2023.100733

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