An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening

Tryptophanyl-tRNA synthetase (TrpRS) links tryptophan to tRNA(Trp), thereby playing an indispensable role in protein translation. Unlike most class I aminoacyl-tRNA synthetases (AARSs), TrpRS functions as a homodimer. Herein, we captured an ‘open-closed’ asymmetric structure of Escherichia coli TrpR...

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Detalles Bibliográficos
Autores principales: Xiang, Manli, Xia, Kaijiang, Chen, Bingyi, Luo, Zhiteng, Yu, Ying, Jiang, Lili, Zhou, Huihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201369/
https://www.ncbi.nlm.nih.gov/pubmed/37070195
http://dx.doi.org/10.1093/nar/gkad278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201369/
https://www.ncbi.nlm.nih.gov/pubmed/37070195
http://dx.doi.org/10.1093/nar/gkad278

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