VEXAS syndrome: a newly discovered systemic rheumatic disorder

VEXAS syndrome is an adult-onset autoinflammatory disease associated with hematologic symptoms. The disease affects primarily males, and leads to death of a significant proportion of the patients. VEXAS syndrome is caused by a somatic mutation of the UBA1 gene in hematopoietic progenitor cells. The...

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Detalles Bibliográficos
Autor principal: Kucharz, Eugenisz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2023
Materias:
Review Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201379/
https://www.ncbi.nlm.nih.gov/pubmed/37223371
http://dx.doi.org/10.5114/reum/163090
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author Kucharz, Eugenisz J.
author_facet Kucharz, Eugenisz J.
author_sort Kucharz, Eugenisz J.
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description VEXAS syndrome is an adult-onset autoinflammatory disease associated with hematologic symptoms. The disease affects primarily males, and leads to death of a significant proportion of the patients. VEXAS syndrome is caused by a somatic mutation of the UBA1 gene in hematopoietic progenitor cells. The clinical picture of the syndrome consists of a number of organ manifestations including those akin to rheumatic diseases, arthritis, myalgia, vasculitis and chondritis.
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spelling pubmed-102013792023-05-23 VEXAS syndrome: a newly discovered systemic rheumatic disorder Kucharz, Eugenisz J. Reumatologia Review Paper VEXAS syndrome is an adult-onset autoinflammatory disease associated with hematologic symptoms. The disease affects primarily males, and leads to death of a significant proportion of the patients. VEXAS syndrome is caused by a somatic mutation of the UBA1 gene in hematopoietic progenitor cells. The clinical picture of the syndrome consists of a number of organ manifestations including those akin to rheumatic diseases, arthritis, myalgia, vasculitis and chondritis. Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie 2023-05-10 2023 /pmc/articles/PMC10201379/ /pubmed/37223371 http://dx.doi.org/10.5114/reum/163090 Text en Copyright: © 2023 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Review Paper
Kucharz, Eugenisz J.
VEXAS syndrome: a newly discovered systemic rheumatic disorder
title VEXAS syndrome: a newly discovered systemic rheumatic disorder
title_full VEXAS syndrome: a newly discovered systemic rheumatic disorder
title_fullStr VEXAS syndrome: a newly discovered systemic rheumatic disorder
title_full_unstemmed VEXAS syndrome: a newly discovered systemic rheumatic disorder
title_short VEXAS syndrome: a newly discovered systemic rheumatic disorder
title_sort vexas syndrome: a newly discovered systemic rheumatic disorder
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201379/
https://www.ncbi.nlm.nih.gov/pubmed/37223371
http://dx.doi.org/10.5114/reum/163090
work_keys_str_mv AT kucharzeugeniszj vexassyndromeanewlydiscoveredsystemicrheumaticdisorder

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