A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells

Precise genome editing requires the resolution of nuclease-induced DNA double strand breaks (DSBs) via the homology-directed repair (HDR) pathway. In mammals, this is typically outcompeted by non-homologous end-joining (NHEJ) that can generate potentially genotoxic insertion/deletion mutations at DS...

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Detalles Bibliográficos
Autores principales: Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201422/
https://www.ncbi.nlm.nih.gov/pubmed/37070192
http://dx.doi.org/10.1093/nar/gkad255

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