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Novel molecular requirements for CRISPR RNA-guided transposition

CRISPR-associated transposases (CASTs) direct DNA integration downstream of target sites using the RNA-guided DNA binding activity of nuclease-deficient CRISPR-Cas systems. Transposition relies on several key protein-protein and protein-DNA interactions, but little is known about the explicit sequen...

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Detalles Bibliográficos
Autores principales:	Walker, Matt W G, Klompe, Sanne E, Zhang, Dennis J, Sternberg, Samuel H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201428/ https://www.ncbi.nlm.nih.gov/pubmed/37078593 http://dx.doi.org/10.1093/nar/gkad270

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