HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription

Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood. In this study, we employed integrative analysis on multi-omics data of six HPV-positive and three HPV-negati...

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Detalles Bibliográficos
Autores principales: Tian, Rui, Huang, Zheying, Li, Lifang, Yuan, Jingping, Zhang, Qinghua, Meng, Lirong, Lang, Bin, Hong, Yongfeng, Zhong, Chaoyue, Tian, Xun, Cui, Zifeng, Jin, Zhuang, Liu, Jiashuo, Huang, Zhaoyue, Wang, Yuyan, Chen, Ye, Hu, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201430/
https://www.ncbi.nlm.nih.gov/pubmed/36864748
http://dx.doi.org/10.1093/nar/gkad105

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