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Flap endonuclease Rad27 cleaves the RNA of R-loop structures to suppress telomere recombination

The long non-coding telomeric RNA transcript TERRA, in the form of an RNA–DNA duplex, regulates telomere recombination. In a screen for nucleases that affects telomere recombination, mutations in DNA2, EXO1, MRE11 and SAE2 cause severe delay in type II survivor formation, indicating that type II tel...

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Detalles Bibliográficos
Autores principales:	Liu, Chia-Chun, Chan, Hsin-Ru, Su, Guan-Chin, Hsieh, Yan-Zhu, Lei, Kai-Hang, Kato, Tomoka, Yu, Tai-Yuan, Kao, Yu-wen, Cheng, Tzu-Hao, Chi, Peter, Lin, Jing-Jer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201435/ https://www.ncbi.nlm.nih.gov/pubmed/36999631 http://dx.doi.org/10.1093/nar/gkad236

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