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Stable bulged G-quadruplexes in the human genome: identification, experimental validation and functionalization

DNA sequence composition determines the topology and stability of G-quadruplexes (G4s). Bulged G-quadruplex structures (G4-Bs) are a subset of G4s characterized by 3D conformations with bulges. Current search algorithms fail to capture stable G4-B, making their genome-wide study infeasible. Here, we...

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Detalles Bibliográficos
Autores principales:	Papp, Csaba, Mukundan, Vineeth T, Jenjaroenpun, Piroon, Winnerdy, Fernaldo Richtia, Ow, Ghim Siong, Phan, Anh Tuân, Kuznetsov, Vladimir A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201450/ https://www.ncbi.nlm.nih.gov/pubmed/37094040 http://dx.doi.org/10.1093/nar/gkad252

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