A self-healable metallohydrogel for drug encapsulations and drug release

A self-healable metallohydrogel (MOG) of Mn(ii) has been prepared using a low molecular weight gelator, Na(2)HL {H(3)L = l-(3,5-di-tert-butyl-2-hydroxy-benzyl)amino aspartic acid}. The MOG has been characterized by MALDI TOF mass spectrometry, rheological studies, IR spectroscopy, and microscopic te...

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Autores principales: Dutta, Mita, Banerjee, Shreya, Mandal, Mahitosh, Bhattacharjee, Manish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201648/
https://www.ncbi.nlm.nih.gov/pubmed/37223407
http://dx.doi.org/10.1039/d3ra00930k
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author Dutta, Mita
Banerjee, Shreya
Mandal, Mahitosh
Bhattacharjee, Manish
author_facet Dutta, Mita
Banerjee, Shreya
Mandal, Mahitosh
Bhattacharjee, Manish
author_sort Dutta, Mita
collection PubMed
description A self-healable metallohydrogel (MOG) of Mn(ii) has been prepared using a low molecular weight gelator, Na(2)HL {H(3)L = l-(3,5-di-tert-butyl-2-hydroxy-benzyl)amino aspartic acid}. The MOG has been characterized by MALDI TOF mass spectrometry, rheological studies, IR spectroscopy, and microscopic techniques. Non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND) and anti-cancer drug gemcitabine (GEM) were encapsulated into the metallohydrogel. The GEM-loaded metallogel (MOG_GEM) shows better delivery and more adverse cytotoxicity than the drug against breast cancer cell lines MDA-MB-468 and 4T1. The anti-cancer property was evaluated with in vitro MTT cytotoxic assay, live-dead assay and cell migration assay. In vitro cytotoxicity assay against RAW 264.7 cell line with the treatment of MOG_IND shows the improved anti-inflammatory response in the case of MOG_IND compared to the drug alone.
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spelling pubmed-102016482023-05-23 A self-healable metallohydrogel for drug encapsulations and drug release Dutta, Mita Banerjee, Shreya Mandal, Mahitosh Bhattacharjee, Manish RSC Adv Chemistry A self-healable metallohydrogel (MOG) of Mn(ii) has been prepared using a low molecular weight gelator, Na(2)HL {H(3)L = l-(3,5-di-tert-butyl-2-hydroxy-benzyl)amino aspartic acid}. The MOG has been characterized by MALDI TOF mass spectrometry, rheological studies, IR spectroscopy, and microscopic techniques. Non-steroidal anti-inflammatory drug (NSAID), indomethacin (IND) and anti-cancer drug gemcitabine (GEM) were encapsulated into the metallohydrogel. The GEM-loaded metallogel (MOG_GEM) shows better delivery and more adverse cytotoxicity than the drug against breast cancer cell lines MDA-MB-468 and 4T1. The anti-cancer property was evaluated with in vitro MTT cytotoxic assay, live-dead assay and cell migration assay. In vitro cytotoxicity assay against RAW 264.7 cell line with the treatment of MOG_IND shows the improved anti-inflammatory response in the case of MOG_IND compared to the drug alone. The Royal Society of Chemistry 2023-05-22 /pmc/articles/PMC10201648/ /pubmed/37223407 http://dx.doi.org/10.1039/d3ra00930k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Dutta, Mita
Banerjee, Shreya
Mandal, Mahitosh
Bhattacharjee, Manish
A self-healable metallohydrogel for drug encapsulations and drug release
title A self-healable metallohydrogel for drug encapsulations and drug release
title_full A self-healable metallohydrogel for drug encapsulations and drug release
title_fullStr A self-healable metallohydrogel for drug encapsulations and drug release
title_full_unstemmed A self-healable metallohydrogel for drug encapsulations and drug release
title_short A self-healable metallohydrogel for drug encapsulations and drug release
title_sort self-healable metallohydrogel for drug encapsulations and drug release
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201648/
https://www.ncbi.nlm.nih.gov/pubmed/37223407
http://dx.doi.org/10.1039/d3ra00930k
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