Extracellular arginine availability modulates eIF2α O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis

BACKGROUND: Nutrient limitations often lead to metabolic stress during cancer initiation and progression. To combat this stress, the enzyme heme oxygenase 1 (HMOX1, commonly known as HO-1) is thought to play a key role as an antioxidant. However, there is a discrepancy between the level of HO-1 mRNA...

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Detalles Bibliográficos
Autores principales: Hung, Yu-Wen, Ouyang, Ching, Ping, Xiaoli, Qi, Yue, Wang, Yi-Chang, Kung, Hsing-Jien, Ann, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201738/
https://www.ncbi.nlm.nih.gov/pubmed/37217939
http://dx.doi.org/10.1186/s12929-023-00924-4

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