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Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study

BACKGROUND: Lifestyle intervention can effectively treat patients with non-alcoholic fatty liver disease (NAFLD). The present study aimed to investigate the association between lifestyle factors with fatty liver index (FLI) in Iranian adults. METHODS: This study enrolled 7114 subjects from the Ravan...

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Autores principales: Kamari, Negin, Fateh, Hawal Lateef, Darbandi, Mitra, Najafi, Farid, Moradi, Mozhgan, Pasdar, Yahya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201767/
https://www.ncbi.nlm.nih.gov/pubmed/37217853
http://dx.doi.org/10.1186/s12876-023-02785-5
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author Kamari, Negin
Fateh, Hawal Lateef
Darbandi, Mitra
Najafi, Farid
Moradi, Mozhgan
Pasdar, Yahya
author_facet Kamari, Negin
Fateh, Hawal Lateef
Darbandi, Mitra
Najafi, Farid
Moradi, Mozhgan
Pasdar, Yahya
author_sort Kamari, Negin
collection PubMed
description BACKGROUND: Lifestyle intervention can effectively treat patients with non-alcoholic fatty liver disease (NAFLD). The present study aimed to investigate the association between lifestyle factors with fatty liver index (FLI) in Iranian adults. METHODS: This study enrolled 7114 subjects from the Ravansar Non-Communicable Diseases (RaNCD) cohort study in western Iran. To compute the FLI score, anthropometric measures, and a few non-invasive liver status indicators were used. Binary logistic regression models examined the association between FLI score and lifestyle. RESULTS: Participants with FLI < 60 had a lower daily energy intake compared to those with FLI ≥ 60 (2740.29 vs. 2840.33 kcal/day, P = < 0.001). The risk of NAFLD in males with high socioeconomic status (SES) was 72% higher than in those with low SES (OR: 1.72; 95% CIs 1.42–2.08). An adjusted logistic regression model showed a significantly negative association between high physical activity and fatty liver index in both men and women. (OR: 0.44, p-value < 0.001 and OR: 0.54, p-value < 0.001, respectively). The odds of NAFLD in female participants with depression were 71% higher than in non-depressed participants (OR: 1.71, 95% CI: 1.06–2.64). Dyslipidemia and high visceral fat area (VFA) were also associated with a significant increase in the risk of NAFLD (P < 0.05). CONCLUSION: In our study, we found that good SES, high VFA, and dyslipidemia were associated with an increased risk of NAFLD. Conversely, high physical activity reduces the risk of NAFLD. Therefore, lifestyle modification may help improve liver function.
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spelling pubmed-102017672023-05-23 Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study Kamari, Negin Fateh, Hawal Lateef Darbandi, Mitra Najafi, Farid Moradi, Mozhgan Pasdar, Yahya BMC Gastroenterol Research BACKGROUND: Lifestyle intervention can effectively treat patients with non-alcoholic fatty liver disease (NAFLD). The present study aimed to investigate the association between lifestyle factors with fatty liver index (FLI) in Iranian adults. METHODS: This study enrolled 7114 subjects from the Ravansar Non-Communicable Diseases (RaNCD) cohort study in western Iran. To compute the FLI score, anthropometric measures, and a few non-invasive liver status indicators were used. Binary logistic regression models examined the association between FLI score and lifestyle. RESULTS: Participants with FLI < 60 had a lower daily energy intake compared to those with FLI ≥ 60 (2740.29 vs. 2840.33 kcal/day, P = < 0.001). The risk of NAFLD in males with high socioeconomic status (SES) was 72% higher than in those with low SES (OR: 1.72; 95% CIs 1.42–2.08). An adjusted logistic regression model showed a significantly negative association between high physical activity and fatty liver index in both men and women. (OR: 0.44, p-value < 0.001 and OR: 0.54, p-value < 0.001, respectively). The odds of NAFLD in female participants with depression were 71% higher than in non-depressed participants (OR: 1.71, 95% CI: 1.06–2.64). Dyslipidemia and high visceral fat area (VFA) were also associated with a significant increase in the risk of NAFLD (P < 0.05). CONCLUSION: In our study, we found that good SES, high VFA, and dyslipidemia were associated with an increased risk of NAFLD. Conversely, high physical activity reduces the risk of NAFLD. Therefore, lifestyle modification may help improve liver function. BioMed Central 2023-05-22 /pmc/articles/PMC10201767/ /pubmed/37217853 http://dx.doi.org/10.1186/s12876-023-02785-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Kamari, Negin
Fateh, Hawal Lateef
Darbandi, Mitra
Najafi, Farid
Moradi, Mozhgan
Pasdar, Yahya
Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title_full Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title_fullStr Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title_full_unstemmed Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title_short Fatty liver index relationship with biomarkers and lifestyle: result from RaNCD cohort study
title_sort fatty liver index relationship with biomarkers and lifestyle: result from rancd cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201767/
https://www.ncbi.nlm.nih.gov/pubmed/37217853
http://dx.doi.org/10.1186/s12876-023-02785-5
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