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Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2). Among many pathogenic pro...

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Detalles Bibliográficos
Autores principales:	Wilk, Elizabeth J., Howton, Timothy C., Fisher, Jennifer L., Oza, Vishal H., Brownlee, Ryan T., McPherson, Kasi C., Cleary, Hannah L., Yoder, Bradley K., George, James F., Mrug, Michal, Lasseigne, Brittany N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201779/ https://www.ncbi.nlm.nih.gov/pubmed/37217845 http://dx.doi.org/10.1186/s10020-023-00664-z

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