A primary gastric Adenosquamous carcinoma: Case report

INTRODUCTION: Adenosquamous carcinoma (ASC) is too rare accounting for <0.5 % of all gastric cancers and has a worse prognosis than adenocarcinoma. CASE PRESENTATION: We report a case of a man with digestive symptoms and epigastric discomfort came to a Gastrointestinal clinic. CT scan of the abdomen and pelvis showed a large mass localized in the gastric fundus and cardia. A PET-CT scan showed a localized lesion in the stomach. Gastroscopy revealed a mass in the gastric fundus. Biopsy from the gastric fundus reported a poorly-differentiated squamous cell carcinoma. A laparoscopic abdominal exploration found a mass and Infected Lymphatic Nodes on the abdomen wall. a second biopsy reported an Adenosquamous cell carcinoma grade II. The therapeutic was open surgery and then chemotherapy. CLINICAL DISCUSSION: Adenosquamous carcinoma usually presents at an advanced stage with metastasis (Chen et al., 2015). In our case, the patient presented with a stage IV tumor; including two lymph nodes metastasis (pN1, N = 2/15) and abdominal wall involvement (pM1). CONCLUSION: Clinicians should be aware of this potential site of adenosquamous carcinoma (ASC) because this carcinoma has a poor prognosis even if diagnosed at an early stage.