Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function

The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T(FH)) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and red...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202069/
https://www.ncbi.nlm.nih.gov/pubmed/37217710
http://dx.doi.org/10.1038/s41590-023-01520-2
Descripción
Sumario:The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T(FH)) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.

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