Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function

The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T(FH)) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and red...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202069/
https://www.ncbi.nlm.nih.gov/pubmed/37217710
http://dx.doi.org/10.1038/s41590-023-01520-2
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description The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T(FH)) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses.
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spelling pubmed-102020692023-05-23 Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function Nat Immunol Research Briefing The magnitude and quality of the germinal center response after vaccination decline with age. We found that T follicular helper (T(FH)) cells are enriched in the dark zone of germinal centers in aged mice, which impairs the expansion of the follicular dendritic cell network upon immunization and reduces antibody responses. Nature Publishing Group US 2023-05-22 /pmc/articles/PMC10202069/ /pubmed/37217710 http://dx.doi.org/10.1038/s41590-023-01520-2 Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title_full Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title_fullStr Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title_full_unstemmed Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title_short Aberrant distribution of T(FH) cells in aged germinal centers reduces stromal cell function
title_sort aberrant distribution of t(fh) cells in aged germinal centers reduces stromal cell function
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202069/
https://www.ncbi.nlm.nih.gov/pubmed/37217710
http://dx.doi.org/10.1038/s41590-023-01520-2

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