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Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere

Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere. This intelligent material contains a s...

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Detalles Bibliográficos
Autores principales: Yin, Yue, Yan, Yaping, Fan, Biao, Huang, Wenping, Zhang, Jie, Hu, Hai-Yan, Li, Xiaoqiong, Xiong, Dongbin, Chou, Shu-Lei, Xiao, Yao, Wang, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202191/
https://www.ncbi.nlm.nih.gov/pubmed/37223478
http://dx.doi.org/10.34133/research.0098
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author Yin, Yue
Yan, Yaping
Fan, Biao
Huang, Wenping
Zhang, Jie
Hu, Hai-Yan
Li, Xiaoqiong
Xiong, Dongbin
Chou, Shu-Lei
Xiao, Yao
Wang, Hai
author_facet Yin, Yue
Yan, Yaping
Fan, Biao
Huang, Wenping
Zhang, Jie
Hu, Hai-Yan
Li, Xiaoqiong
Xiong, Dongbin
Chou, Shu-Lei
Xiao, Yao
Wang, Hai
author_sort Yin, Yue
collection PubMed
description Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere. This intelligent material contains a superadsorbed silicon dioxide sphere, sufficient loading space, a nanoscale hole on its surface, a robust shell, and an outer bilayer, and it could load both programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents, protect these small molecules during the systemic circulation, and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation, thereby realizing dual attack of photodynamic therapy and immunotherapy on tumors. Importantly, we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses, further enhancing the therapeutic effect. Thus, a novel combination therapy “PD-1/PD-L1 immune checkpoint blockade + photodynamic therapy + fasting-mimicking diet”was developed with the aid of our materials, which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing mice. The concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future.
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spelling pubmed-102021912023-05-23 Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere Yin, Yue Yan, Yaping Fan, Biao Huang, Wenping Zhang, Jie Hu, Hai-Yan Li, Xiaoqiong Xiong, Dongbin Chou, Shu-Lei Xiao, Yao Wang, Hai Research (Wash D C) Research Article Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality, and the efficacy of monotherapy for TNBC is still disappointing. Here, we developed a novel combination therapy for TNBC based on a multifunctional nanohollow carbon sphere. This intelligent material contains a superadsorbed silicon dioxide sphere, sufficient loading space, a nanoscale hole on its surface, a robust shell, and an outer bilayer, and it could load both programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) small-molecule immune checkpoints and small-molecule photosensitizers with excellent loading contents, protect these small molecules during the systemic circulation, and achieve accumulation of them in tumor sites after systemic administration followed by the application of laser irradiation, thereby realizing dual attack of photodynamic therapy and immunotherapy on tumors. Importantly, we integrated the fasting-mimicking diet condition that can further enhance the cellular uptake efficiency of nanoparticles in tumor cells and amplify the immune responses, further enhancing the therapeutic effect. Thus, a novel combination therapy “PD-1/PD-L1 immune checkpoint blockade + photodynamic therapy + fasting-mimicking diet”was developed with the aid of our materials, which eventually achieved a marked therapeutic effect in 4T1-tumor-bearing mice. The concept can also be applied to the clinical treatment of human TNBC with guiding significance in the future. AAAS 2023-04-11 /pmc/articles/PMC10202191/ /pubmed/37223478 http://dx.doi.org/10.34133/research.0098 Text en Copyright © 2023 Yue Yin et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Yin, Yue
Yan, Yaping
Fan, Biao
Huang, Wenping
Zhang, Jie
Hu, Hai-Yan
Li, Xiaoqiong
Xiong, Dongbin
Chou, Shu-Lei
Xiao, Yao
Wang, Hai
Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title_full Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title_fullStr Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title_full_unstemmed Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title_short Novel Combination Therapy for Triple-Negative Breast Cancer based on an Intelligent Hollow Carbon Sphere
title_sort novel combination therapy for triple-negative breast cancer based on an intelligent hollow carbon sphere
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202191/
https://www.ncbi.nlm.nih.gov/pubmed/37223478
http://dx.doi.org/10.34133/research.0098
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