An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity

The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome. Recent studies uncovered a role for cholesterol metabolism in the SARS-CoV-2 life cycle...

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Detalles Bibliográficos
Autores principales: Wing, Peter A. C., Schmidt, Nathalie M., Peters, Rory, Erdmann, Maximilian, Brown, Rachel, Wang, Hao, Swadling, Leo, Newman, Joseph, Thakur, Nazia, Shionoya, Kaho, Morgan, Sophie B., Hinks, Timothy SC, Watashi, Koichi, Bailey, Dalan, Hansen, Scott B., Davidson, Andrew D., Maini, Mala K., McKeating, Jane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202285/
https://www.ncbi.nlm.nih.gov/pubmed/37134108
http://dx.doi.org/10.1371/journal.ppat.1011323

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