4′-Deoxypyridoxine disrupts vitamin B(6) homeostasis in Escherichia coli K12 through combined inhibition of cumulative B(6) uptake and PLP-dependent enzyme activity

Pyridoxal 5′-phosphate (PLP) is the active form of vitamin B(6) and a cofactor for many essential metabolic processes such as amino acid biosynthesis and one carbon metabolism. 4’-deoxypyridoxine (4dPN) is a long known B(6) antimetabolite but its mechanism of action was not totally clear. By explori...

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Detalles Bibliográficos
Autores principales: Babor, Jill, Tramonti, Angela, Nardella, Caterina, Deutschbauer, Adam, Contestabile, Roberto, de Crécy-Lagard, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Microbial Physiology, Biochemistry and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202323/
https://www.ncbi.nlm.nih.gov/pubmed/37040165
http://dx.doi.org/10.1099/mic.0.001319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202323/
https://www.ncbi.nlm.nih.gov/pubmed/37040165
http://dx.doi.org/10.1099/mic.0.001319

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