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A journey with type IX secretion system effectors: selection, transport, processing and activities

The type IX secretion system (T9SS) is a multiprotein machine distributed in Bacteroidota and responsible for the secretion of various proteins across the outer membrane. Secreted effectors can be either delivered into the medium or anchored to the cell surface. The T9SS is composed of a transenvelo...

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Autores principales: Paillat, Maëlle, Lunar Silva, Ignacio, Cascales, Eric, Doan, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202324/
https://www.ncbi.nlm.nih.gov/pubmed/37043368
http://dx.doi.org/10.1099/mic.0.001320
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author Paillat, Maëlle
Lunar Silva, Ignacio
Cascales, Eric
Doan, Thierry
author_facet Paillat, Maëlle
Lunar Silva, Ignacio
Cascales, Eric
Doan, Thierry
author_sort Paillat, Maëlle
collection PubMed
description The type IX secretion system (T9SS) is a multiprotein machine distributed in Bacteroidota and responsible for the secretion of various proteins across the outer membrane. Secreted effectors can be either delivered into the medium or anchored to the cell surface. The T9SS is composed of a transenvelope complex consisting of proton-motive force-dependent motors connected to a membrane-associated ring and outer membrane translocons, and a cell-surface anchoring complex that processes effectors once translocated. The T9SS is involved in pathogenesis, metal acquisition, carbohydrate degradation, S-layer biogenesis and gliding motility. The broad spectrum of functions is linked to a highly versatile repertoire of effectors including metallophores, enzymes, toxins and adhesins, that all possess specific signatures to be recruited and transported by the apparatus. This review summarizes the current knowledge on T9SS substrate secretion signals, transport, processing and activities.
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spelling pubmed-102023242023-05-23 A journey with type IX secretion system effectors: selection, transport, processing and activities Paillat, Maëlle Lunar Silva, Ignacio Cascales, Eric Doan, Thierry Microbiology (Reading) Microbial Cell Surfaces The type IX secretion system (T9SS) is a multiprotein machine distributed in Bacteroidota and responsible for the secretion of various proteins across the outer membrane. Secreted effectors can be either delivered into the medium or anchored to the cell surface. The T9SS is composed of a transenvelope complex consisting of proton-motive force-dependent motors connected to a membrane-associated ring and outer membrane translocons, and a cell-surface anchoring complex that processes effectors once translocated. The T9SS is involved in pathogenesis, metal acquisition, carbohydrate degradation, S-layer biogenesis and gliding motility. The broad spectrum of functions is linked to a highly versatile repertoire of effectors including metallophores, enzymes, toxins and adhesins, that all possess specific signatures to be recruited and transported by the apparatus. This review summarizes the current knowledge on T9SS substrate secretion signals, transport, processing and activities. Microbiology Society 2023-04-12 /pmc/articles/PMC10202324/ /pubmed/37043368 http://dx.doi.org/10.1099/mic.0.001320 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
spellingShingle Microbial Cell Surfaces
Paillat, Maëlle
Lunar Silva, Ignacio
Cascales, Eric
Doan, Thierry
A journey with type IX secretion system effectors: selection, transport, processing and activities
title A journey with type IX secretion system effectors: selection, transport, processing and activities
title_full A journey with type IX secretion system effectors: selection, transport, processing and activities
title_fullStr A journey with type IX secretion system effectors: selection, transport, processing and activities
title_full_unstemmed A journey with type IX secretion system effectors: selection, transport, processing and activities
title_short A journey with type IX secretion system effectors: selection, transport, processing and activities
title_sort journey with type ix secretion system effectors: selection, transport, processing and activities
topic Microbial Cell Surfaces
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202324/
https://www.ncbi.nlm.nih.gov/pubmed/37043368
http://dx.doi.org/10.1099/mic.0.001320
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