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A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells

Plasmodium vivax, one of the major species associated with human malaria, continues to be a major public health problem in many parts of the world. Numerous studies related to vivax malaria have described quantitative haematological findings (level of haemoglobin, thrombocytopaenia, haematocrit valu...

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Autores principales: Biswal, Debasish, Mirdha, Bijay Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202396/
https://www.ncbi.nlm.nih.gov/pubmed/37223061
http://dx.doi.org/10.1099/acmi.0.000461.v3
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author Biswal, Debasish
Mirdha, Bijay Ranjan
author_facet Biswal, Debasish
Mirdha, Bijay Ranjan
author_sort Biswal, Debasish
collection PubMed
description Plasmodium vivax, one of the major species associated with human malaria, continues to be a major public health problem in many parts of the world. Numerous studies related to vivax malaria have described quantitative haematological findings (level of haemoglobin, thrombocytopaenia, haematocrit values), but diverse morphological changes of parasite forms within infected red blood cells (iRBCs) have been mentioned only in few studies. Here we report a case of a 13-year-old boy who presented with fever, significant low platelet counts and hypovolaemia that created a diagnostic dilemma. Detection of microgametocytes by microscopic examinations, further confirmed by multiplex nested PCR assays and response to anti-malarials, helped to make the diagnosis. We present an atypical case of vivax malaria with a review of morpho-variations of iRBCs and have summarized the characteristics that aid in creating increased awareness among laboratory health professionals and public health workers.
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spelling pubmed-102023962023-05-23 A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells Biswal, Debasish Mirdha, Bijay Ranjan Access Microbiol Case Reports Plasmodium vivax, one of the major species associated with human malaria, continues to be a major public health problem in many parts of the world. Numerous studies related to vivax malaria have described quantitative haematological findings (level of haemoglobin, thrombocytopaenia, haematocrit values), but diverse morphological changes of parasite forms within infected red blood cells (iRBCs) have been mentioned only in few studies. Here we report a case of a 13-year-old boy who presented with fever, significant low platelet counts and hypovolaemia that created a diagnostic dilemma. Detection of microgametocytes by microscopic examinations, further confirmed by multiplex nested PCR assays and response to anti-malarials, helped to make the diagnosis. We present an atypical case of vivax malaria with a review of morpho-variations of iRBCs and have summarized the characteristics that aid in creating increased awareness among laboratory health professionals and public health workers. Microbiology Society 2023-04-25 /pmc/articles/PMC10202396/ /pubmed/37223061 http://dx.doi.org/10.1099/acmi.0.000461.v3 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Case Reports
Biswal, Debasish
Mirdha, Bijay Ranjan
A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title_full A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title_fullStr A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title_full_unstemmed A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title_short A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
title_sort case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202396/
https://www.ncbi.nlm.nih.gov/pubmed/37223061
http://dx.doi.org/10.1099/acmi.0.000461.v3
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