APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

Cells have evolved the DNA damage response (DDR) pathways in response to DNA replication stress or DNA damage. In the ATR-Chk1 DDR pathway, it has been proposed that ATR is recruited to RPA-coated single-stranded DNA (ssDNA) by direct ATRIP-RPA interaction. However, it remains elusive how ATRIP is r...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Yunfeng, Li, Jia, Zhao, Haichao, McMahon, Anne, McGhee, Kelly, Yan, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202453/
https://www.ncbi.nlm.nih.gov/pubmed/37216274
http://dx.doi.org/10.7554/eLife.82324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202453/
https://www.ncbi.nlm.nih.gov/pubmed/37216274
http://dx.doi.org/10.7554/eLife.82324

Ejemplares similares