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Condensation of LINE-1 is critical for retrotransposition

LINE-1 (L1) is the only autonomously active retrotransposon in the human genome, and accounts for 17% of the human genome. The L1 mRNA encodes two proteins, ORF1p and ORF2p, both essential for retrotransposition. ORF2p has reverse transcriptase and endonuclease activities, while ORF1p is a homotrime...

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Detalles Bibliográficos
Autores principales:	Sil, Srinjoy, Keegan, Sarah, Ettefa, Farida, Denes, Lance T, Boeke, Jef D, Holt, Liam J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202459/ https://www.ncbi.nlm.nih.gov/pubmed/37114770 http://dx.doi.org/10.7554/eLife.82991

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