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First molecular detection of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felis catus) from an urban area in eastern Amazon
BACKGROUND: Domestic cats have been implicated as accidental hosts of Leishmania sp. However, in recent years, the recurrent description of new cases in endemic and nonendemic areas draw attention to the potential epidemiological role of cats as reservoir hosts. Although dogs are considered urban re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202461/ https://www.ncbi.nlm.nih.gov/pubmed/37223440 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0048 |
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author | Aguiar, Délia Cristina Figueira Nascimento, Daniela de Nazaré dos Santos Penner, Dinaiara Fragoso de Castro, Brena do Socorro Lima Virgolino, Rodrigo Rodrigues Neves, Alan Marcel Pamplona Siqueira, Andrei dos Santos Gonçalves, Evonnildo Costa |
author_facet | Aguiar, Délia Cristina Figueira Nascimento, Daniela de Nazaré dos Santos Penner, Dinaiara Fragoso de Castro, Brena do Socorro Lima Virgolino, Rodrigo Rodrigues Neves, Alan Marcel Pamplona Siqueira, Andrei dos Santos Gonçalves, Evonnildo Costa |
author_sort | Aguiar, Délia Cristina Figueira |
collection | PubMed |
description | BACKGROUND: Domestic cats have been implicated as accidental hosts of Leishmania sp. However, in recent years, the recurrent description of new cases in endemic and nonendemic areas draw attention to the potential epidemiological role of cats as reservoir hosts. Although dogs are considered urban reservoirs, cats could act as a secondary natural reservoirs in these areas. Thus, feline leishmaniasis has become an emerging disease in several countries worldwide. CASE PRESENTATION: This study aimed to describe the first case of feline leishmaniasis in a stray animal that presented lesions compatible with the disease in Belém, Pará, Brazil, an important urban area in eastern Amazon. Serological tests for Leishmania infantum (ELISA and IFA) were nonreactive, whereas histopathological examination indicated infectious dermatitis caused by Leishmania spp. or Toxoplasma gondii. Cytopathological study of lesion aspirate confirmed the presence of Leishmania sp. amastigotes within macrophages. Finally, molecular analyses revealed that the feline infection was caused by Leishmania (Leishmania) infantum chagasi. CONCLUSION: To the best of the authors’ knowledge, this study reports the first case of natural infection by Leishmania (Leishmania) infantum chagasi in a feline from eastern Amazon. These findings suggest domestic cats as potential secondary reservoir hosts of Leishmania spp. in Belém, which reinforces the importance of further epidemiological investigation of feline leishmaniasis, especially in urban areas with human cases. |
format | Online Article Text |
id | pubmed-10202461 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
record_format | MEDLINE/PubMed |
spelling | pubmed-102024612023-05-23 First molecular detection of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felis catus) from an urban area in eastern Amazon Aguiar, Délia Cristina Figueira Nascimento, Daniela de Nazaré dos Santos Penner, Dinaiara Fragoso de Castro, Brena do Socorro Lima Virgolino, Rodrigo Rodrigues Neves, Alan Marcel Pamplona Siqueira, Andrei dos Santos Gonçalves, Evonnildo Costa J Venom Anim Toxins Incl Trop Dis Case Report BACKGROUND: Domestic cats have been implicated as accidental hosts of Leishmania sp. However, in recent years, the recurrent description of new cases in endemic and nonendemic areas draw attention to the potential epidemiological role of cats as reservoir hosts. Although dogs are considered urban reservoirs, cats could act as a secondary natural reservoirs in these areas. Thus, feline leishmaniasis has become an emerging disease in several countries worldwide. CASE PRESENTATION: This study aimed to describe the first case of feline leishmaniasis in a stray animal that presented lesions compatible with the disease in Belém, Pará, Brazil, an important urban area in eastern Amazon. Serological tests for Leishmania infantum (ELISA and IFA) were nonreactive, whereas histopathological examination indicated infectious dermatitis caused by Leishmania spp. or Toxoplasma gondii. Cytopathological study of lesion aspirate confirmed the presence of Leishmania sp. amastigotes within macrophages. Finally, molecular analyses revealed that the feline infection was caused by Leishmania (Leishmania) infantum chagasi. CONCLUSION: To the best of the authors’ knowledge, this study reports the first case of natural infection by Leishmania (Leishmania) infantum chagasi in a feline from eastern Amazon. These findings suggest domestic cats as potential secondary reservoir hosts of Leishmania spp. in Belém, which reinforces the importance of further epidemiological investigation of feline leishmaniasis, especially in urban areas with human cases. Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2023-05-22 /pmc/articles/PMC10202461/ /pubmed/37223440 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0048 Text en https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Aguiar, Délia Cristina Figueira Nascimento, Daniela de Nazaré dos Santos Penner, Dinaiara Fragoso de Castro, Brena do Socorro Lima Virgolino, Rodrigo Rodrigues Neves, Alan Marcel Pamplona Siqueira, Andrei dos Santos Gonçalves, Evonnildo Costa First molecular detection of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felis catus) from an urban area in eastern Amazon |
title | First molecular detection of Leishmania (Leishmania) infantum
chagasi in a domestic cat (Felis catus) from an
urban area in eastern Amazon |
title_full | First molecular detection of Leishmania (Leishmania) infantum
chagasi in a domestic cat (Felis catus) from an
urban area in eastern Amazon |
title_fullStr | First molecular detection of Leishmania (Leishmania) infantum
chagasi in a domestic cat (Felis catus) from an
urban area in eastern Amazon |
title_full_unstemmed | First molecular detection of Leishmania (Leishmania) infantum
chagasi in a domestic cat (Felis catus) from an
urban area in eastern Amazon |
title_short | First molecular detection of Leishmania (Leishmania) infantum
chagasi in a domestic cat (Felis catus) from an
urban area in eastern Amazon |
title_sort | first molecular detection of leishmania (leishmania) infantum
chagasi in a domestic cat (felis catus) from an
urban area in eastern amazon |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202461/ https://www.ncbi.nlm.nih.gov/pubmed/37223440 http://dx.doi.org/10.1590/1678-9199-JVATITD-2022-0048 |
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