Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm

A 50-year-old female patient of heavily pre-treated (chemotherapy and multiple treatment-resistant) and progressive intermediate-grade metastatic neuroendocrine neoplasm is presented, wherein the lesions showed mixed response following topotecan treatment and multiple hepatic metastasis showed incre...

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Autores principales: Loharkar, Sarvesh, Basu, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202582/
https://www.ncbi.nlm.nih.gov/pubmed/37223630
http://dx.doi.org/10.1055/s-0043-1760761
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author Loharkar, Sarvesh
Basu, Sandip
author_facet Loharkar, Sarvesh
Basu, Sandip
author_sort Loharkar, Sarvesh
collection PubMed
description A 50-year-old female patient of heavily pre-treated (chemotherapy and multiple treatment-resistant) and progressive intermediate-grade metastatic neuroendocrine neoplasm is presented, wherein the lesions showed mixed response following topotecan treatment and multiple hepatic metastasis showed increase in the SSTR expression and decrease in FDG concentration on dual-tracer PET/CT ( (68) Ga-DOTATATE and (18) F-FDG PET/CT). Such observation allowed (177) Lu-DOTATATE PRRT to be considered for an advanced, symptomatic, and multiple treatment-resistant patient with limited palliative treatment options left.
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spelling pubmed-102025822023-05-23 Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm Loharkar, Sarvesh Basu, Sandip World J Nucl Med A 50-year-old female patient of heavily pre-treated (chemotherapy and multiple treatment-resistant) and progressive intermediate-grade metastatic neuroendocrine neoplasm is presented, wherein the lesions showed mixed response following topotecan treatment and multiple hepatic metastasis showed increase in the SSTR expression and decrease in FDG concentration on dual-tracer PET/CT ( (68) Ga-DOTATATE and (18) F-FDG PET/CT). Such observation allowed (177) Lu-DOTATATE PRRT to be considered for an advanced, symptomatic, and multiple treatment-resistant patient with limited palliative treatment options left. Thieme Medical and Scientific Publishers Pvt. Ltd. 2023-04-28 /pmc/articles/PMC10202582/ /pubmed/37223630 http://dx.doi.org/10.1055/s-0043-1760761 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Loharkar, Sarvesh
Basu, Sandip
Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title_full Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title_fullStr Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title_full_unstemmed Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title_short Post-Topotecan Mixed Response and ‘Redifferentiation-akin’ Phenomenon on Dual Tracer PET-CT in Multiple Treatment-Resistant Metastatic Neuroendocrine Neoplasm
title_sort post-topotecan mixed response and ‘redifferentiation-akin’ phenomenon on dual tracer pet-ct in multiple treatment-resistant metastatic neuroendocrine neoplasm
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202582/
https://www.ncbi.nlm.nih.gov/pubmed/37223630
http://dx.doi.org/10.1055/s-0043-1760761
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AT basusandip posttopotecanmixedresponseandredifferentiationakinphenomenonondualtracerpetctinmultipletreatmentresistantmetastaticneuroendocrineneoplasm

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