Identification of Polymorphisms in the HERC2-OCA2 Gene Locus and their Association with Feather Color in Quail

Mutations in the HERC2 and OCA2 genes have the potential to affect pigment deposition and alter feather color in birds. Therefore, in this study, we evaluated HERC2-OCA2 gene locus polymorphisms in Korean and Beijing white quails using RNA-Seq and KASP technology. The expression levels of HERC2 and...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaohui, Qi, Yanxia, Pang, Youzhi, Yuan, Bingjie, Li, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Poultry Science Association 2023
Materias:
«Reseacrh Note»
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202620/
https://www.ncbi.nlm.nih.gov/pubmed/37234755
http://dx.doi.org/10.2141/jpsa.2023013
Descripción
Sumario:Mutations in the HERC2 and OCA2 genes have the potential to affect pigment deposition and alter feather color in birds. Therefore, in this study, we evaluated HERC2-OCA2 gene locus polymorphisms in Korean and Beijing white quails using RNA-Seq and KASP technology. The expression levels of HERC2 and OCA2 mRNA in skin tissues were analyzed using RT-qPCR. Ten single nucleotide polymorphisms were identified by RNA-Seq, of which three (n.117627564T>A, n.117674275T>G, n.117686226A>C) exhibited significant association with feather color in quail. The expression of OCA2 mRNA was significantly lower in the skin of Beijing white quails than that in the skin of Korean quails. These results suggested that variants in HERC2-OCA2 intergenic region could influence the expression of OCA2, which may underlie diluted feather color in the Beijing white quail.

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