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Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits

Soft tissue sarcomas (STSs) are a heterogeneous group of tumors that originate from mesenchymal cells. p53 is frequently mutated in human STS. In this study, we found that the loss of p53 in mesenchymal stem cells (MSCs) mainly causes adult undifferentiated soft tissue sarcoma (USTS). MSCs lacking p...

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Detalles Bibliográficos
Autores principales:	Sorimachi, Yuriko, Kobayashi, Hiroshi, Shiozawa, Yusuke, Koide, Shuhei, Nakato, Ryuichiro, Shimizu, Yukiko, Okamura, Tadashi, Shirahige, Katsuhiko, Iwama, Atsushi, Goda, Nobuhito, Takubo, Kaiyo, Takubo, Keiyo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202654/ https://www.ncbi.nlm.nih.gov/pubmed/37059101 http://dx.doi.org/10.1016/j.stemcr.2023.03.009

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