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Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes

Triadin knockout syndrome (TKOS) is a malignant arrhythmia disorder caused by recessive null variants in TRDN-encoded cardiac triadin. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) were generated from two unrelated TKOS patients and an unrelated control. CRISPR-Cas9 gene editing wa...

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Detalles Bibliográficos
Autores principales:	Clemens, Daniel J., Ye, Dan, Wang, Lili, Kim, C.S. John, Zhou, Wei, Dotzler, Steven M., Tester, David J., Marty, Isabelle, Knollmann, Bjorn C., Ackerman, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202692/ https://www.ncbi.nlm.nih.gov/pubmed/37163978 http://dx.doi.org/10.1016/j.stemcr.2023.04.005

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