Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

Mitochondrial dysfunction involving mitochondria-associated ER membrane (MAM) dysregulation is implicated in the pathogenesis of late-onset neurodegenerative diseases, but understanding is limited for rare early-onset conditions. Loss of the MAM-resident protein WFS1 causes Wolfram syndrome (WS), a...

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Detalles Bibliográficos
Autores principales: Zatyka, Malgorzata, Rosenstock, Tatiana R., Sun, Congxin, Palhegyi, Adina M., Hughes, Georgina W., Lara-Reyna, Samuel, Astuti, Dewi, di Maio, Alessandro, Sciauvaud, Axel, Korsgen, Miriam E., Stanulovic, Vesna, Kocak, Gamze, Rak, Malgorzata, Pourtoy-Brasselet, Sandra, Winter, Katherine, Varga, Thiago, Jarrige, Margot, Polvèche, Hélène, Correia, Joao, Frickel, Eva-Maria, Hoogenkamp, Maarten, Ward, Douglas G., Aubry, Laetitia, Barrett, Timothy, Sarkar, Sovan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202695/
https://www.ncbi.nlm.nih.gov/pubmed/37163979
http://dx.doi.org/10.1016/j.stemcr.2023.04.002

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