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A shared neural basis underlying psychiatric comorbidity
Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAG...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202801/ https://www.ncbi.nlm.nih.gov/pubmed/37095248 http://dx.doi.org/10.1038/s41591-023-02317-4 |
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author | Xie, Chao Xiang, Shitong Shen, Chun Peng, Xuerui Kang, Jujiao Li, Yuzhu Cheng, Wei He, Shiqi Bobou, Marina Broulidakis, M. John van Noort, Betteke Maria Zhang, Zuo Robinson, Lauren Vaidya, Nilakshi Winterer, Jeanne Zhang, Yuning King, Sinead Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaître, Hervé Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Fröhner, Juliane H. Schmidt, Ulrike Sinclair, Julia Smolka, Michael N. Stringaris, Argyris Walter, Henrik Whelan, Robert Desrivières, Sylvane Sahakian, Barbara J. Robbins, Trevor W. Schumann, Gunter Jia, Tianye Feng, Jianfeng |
author_facet | Xie, Chao Xiang, Shitong Shen, Chun Peng, Xuerui Kang, Jujiao Li, Yuzhu Cheng, Wei He, Shiqi Bobou, Marina Broulidakis, M. John van Noort, Betteke Maria Zhang, Zuo Robinson, Lauren Vaidya, Nilakshi Winterer, Jeanne Zhang, Yuning King, Sinead Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaître, Hervé Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Fröhner, Juliane H. Schmidt, Ulrike Sinclair, Julia Smolka, Michael N. Stringaris, Argyris Walter, Henrik Whelan, Robert Desrivières, Sylvane Sahakian, Barbara J. Robbins, Trevor W. Schumann, Gunter Jia, Tianye Feng, Jianfeng |
author_sort | Xie, Chao |
collection | PubMed |
description | Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities. |
format | Online Article Text |
id | pubmed-10202801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-102028012023-05-24 A shared neural basis underlying psychiatric comorbidity Xie, Chao Xiang, Shitong Shen, Chun Peng, Xuerui Kang, Jujiao Li, Yuzhu Cheng, Wei He, Shiqi Bobou, Marina Broulidakis, M. John van Noort, Betteke Maria Zhang, Zuo Robinson, Lauren Vaidya, Nilakshi Winterer, Jeanne Zhang, Yuning King, Sinead Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaître, Hervé Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Fröhner, Juliane H. Schmidt, Ulrike Sinclair, Julia Smolka, Michael N. Stringaris, Argyris Walter, Henrik Whelan, Robert Desrivières, Sylvane Sahakian, Barbara J. Robbins, Trevor W. Schumann, Gunter Jia, Tianye Feng, Jianfeng Nat Med Article Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities. Nature Publishing Group US 2023-04-24 2023 /pmc/articles/PMC10202801/ /pubmed/37095248 http://dx.doi.org/10.1038/s41591-023-02317-4 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Xie, Chao Xiang, Shitong Shen, Chun Peng, Xuerui Kang, Jujiao Li, Yuzhu Cheng, Wei He, Shiqi Bobou, Marina Broulidakis, M. John van Noort, Betteke Maria Zhang, Zuo Robinson, Lauren Vaidya, Nilakshi Winterer, Jeanne Zhang, Yuning King, Sinead Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaître, Hervé Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Fröhner, Juliane H. Schmidt, Ulrike Sinclair, Julia Smolka, Michael N. Stringaris, Argyris Walter, Henrik Whelan, Robert Desrivières, Sylvane Sahakian, Barbara J. Robbins, Trevor W. Schumann, Gunter Jia, Tianye Feng, Jianfeng A shared neural basis underlying psychiatric comorbidity |
title | A shared neural basis underlying psychiatric comorbidity |
title_full | A shared neural basis underlying psychiatric comorbidity |
title_fullStr | A shared neural basis underlying psychiatric comorbidity |
title_full_unstemmed | A shared neural basis underlying psychiatric comorbidity |
title_short | A shared neural basis underlying psychiatric comorbidity |
title_sort | shared neural basis underlying psychiatric comorbidity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202801/ https://www.ncbi.nlm.nih.gov/pubmed/37095248 http://dx.doi.org/10.1038/s41591-023-02317-4 |
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