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A shared neural basis underlying psychiatric comorbidity

Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAG...

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Autores principales: Xie, Chao, Xiang, Shitong, Shen, Chun, Peng, Xuerui, Kang, Jujiao, Li, Yuzhu, Cheng, Wei, He, Shiqi, Bobou, Marina, Broulidakis, M. John, van Noort, Betteke Maria, Zhang, Zuo, Robinson, Lauren, Vaidya, Nilakshi, Winterer, Jeanne, Zhang, Yuning, King, Sinead, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L. W., Bromberg, Uli, Büchel, Christian, Flor, Herta, Grigis, Antoine, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Lemaître, Hervé, Martinot, Jean-Luc, Martinot, Marie-Laure Paillère, Nees, Frauke, Orfanos, Dimitri Papadopoulos, Paus, Tomáš, Poustka, Luise, Fröhner, Juliane H., Schmidt, Ulrike, Sinclair, Julia, Smolka, Michael N., Stringaris, Argyris, Walter, Henrik, Whelan, Robert, Desrivières, Sylvane, Sahakian, Barbara J., Robbins, Trevor W., Schumann, Gunter, Jia, Tianye, Feng, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202801/
https://www.ncbi.nlm.nih.gov/pubmed/37095248
http://dx.doi.org/10.1038/s41591-023-02317-4
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author Xie, Chao
Xiang, Shitong
Shen, Chun
Peng, Xuerui
Kang, Jujiao
Li, Yuzhu
Cheng, Wei
He, Shiqi
Bobou, Marina
Broulidakis, M. John
van Noort, Betteke Maria
Zhang, Zuo
Robinson, Lauren
Vaidya, Nilakshi
Winterer, Jeanne
Zhang, Yuning
King, Sinead
Banaschewski, Tobias
Barker, Gareth J.
Bokde, Arun L. W.
Bromberg, Uli
Büchel, Christian
Flor, Herta
Grigis, Antoine
Garavan, Hugh
Gowland, Penny
Heinz, Andreas
Ittermann, Bernd
Lemaître, Hervé
Martinot, Jean-Luc
Martinot, Marie-Laure Paillère
Nees, Frauke
Orfanos, Dimitri Papadopoulos
Paus, Tomáš
Poustka, Luise
Fröhner, Juliane H.
Schmidt, Ulrike
Sinclair, Julia
Smolka, Michael N.
Stringaris, Argyris
Walter, Henrik
Whelan, Robert
Desrivières, Sylvane
Sahakian, Barbara J.
Robbins, Trevor W.
Schumann, Gunter
Jia, Tianye
Feng, Jianfeng
author_facet Xie, Chao
Xiang, Shitong
Shen, Chun
Peng, Xuerui
Kang, Jujiao
Li, Yuzhu
Cheng, Wei
He, Shiqi
Bobou, Marina
Broulidakis, M. John
van Noort, Betteke Maria
Zhang, Zuo
Robinson, Lauren
Vaidya, Nilakshi
Winterer, Jeanne
Zhang, Yuning
King, Sinead
Banaschewski, Tobias
Barker, Gareth J.
Bokde, Arun L. W.
Bromberg, Uli
Büchel, Christian
Flor, Herta
Grigis, Antoine
Garavan, Hugh
Gowland, Penny
Heinz, Andreas
Ittermann, Bernd
Lemaître, Hervé
Martinot, Jean-Luc
Martinot, Marie-Laure Paillère
Nees, Frauke
Orfanos, Dimitri Papadopoulos
Paus, Tomáš
Poustka, Luise
Fröhner, Juliane H.
Schmidt, Ulrike
Sinclair, Julia
Smolka, Michael N.
Stringaris, Argyris
Walter, Henrik
Whelan, Robert
Desrivières, Sylvane
Sahakian, Barbara J.
Robbins, Trevor W.
Schumann, Gunter
Jia, Tianye
Feng, Jianfeng
author_sort Xie, Chao
collection PubMed
description Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities.
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spelling pubmed-102028012023-05-24 A shared neural basis underlying psychiatric comorbidity Xie, Chao Xiang, Shitong Shen, Chun Peng, Xuerui Kang, Jujiao Li, Yuzhu Cheng, Wei He, Shiqi Bobou, Marina Broulidakis, M. John van Noort, Betteke Maria Zhang, Zuo Robinson, Lauren Vaidya, Nilakshi Winterer, Jeanne Zhang, Yuning King, Sinead Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L. W. Bromberg, Uli Büchel, Christian Flor, Herta Grigis, Antoine Garavan, Hugh Gowland, Penny Heinz, Andreas Ittermann, Bernd Lemaître, Hervé Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Orfanos, Dimitri Papadopoulos Paus, Tomáš Poustka, Luise Fröhner, Juliane H. Schmidt, Ulrike Sinclair, Julia Smolka, Michael N. Stringaris, Argyris Walter, Henrik Whelan, Robert Desrivières, Sylvane Sahakian, Barbara J. Robbins, Trevor W. Schumann, Gunter Jia, Tianye Feng, Jianfeng Nat Med Article Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study, we used a large longitudinal neuroimaging cohort from adolescence to young adulthood (IMAGEN) to define a neuropsychopathological (NP) factor across externalizing and internalizing symptoms using multitask connectomes. We demonstrate that this NP factor might represent a unified, genetically determined, delayed development of the prefrontal cortex that further leads to poor executive function. We also show this NP factor to be reproducible in multiple developmental periods, from preadolescence to early adulthood, and generalizable to the resting-state connectome and clinical samples (the ADHD-200 Sample and the STRATIFY & ESTRA Project). In conclusion, we identify a reproducible and general neural basis underlying symptoms of multiple mental health disorders, bridging multidimensional evidence from behavioral, neuroimaging and genetic substrates. These findings may help to develop new therapeutic interventions for psychiatric comorbidities. Nature Publishing Group US 2023-04-24 2023 /pmc/articles/PMC10202801/ /pubmed/37095248 http://dx.doi.org/10.1038/s41591-023-02317-4 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Xie, Chao
Xiang, Shitong
Shen, Chun
Peng, Xuerui
Kang, Jujiao
Li, Yuzhu
Cheng, Wei
He, Shiqi
Bobou, Marina
Broulidakis, M. John
van Noort, Betteke Maria
Zhang, Zuo
Robinson, Lauren
Vaidya, Nilakshi
Winterer, Jeanne
Zhang, Yuning
King, Sinead
Banaschewski, Tobias
Barker, Gareth J.
Bokde, Arun L. W.
Bromberg, Uli
Büchel, Christian
Flor, Herta
Grigis, Antoine
Garavan, Hugh
Gowland, Penny
Heinz, Andreas
Ittermann, Bernd
Lemaître, Hervé
Martinot, Jean-Luc
Martinot, Marie-Laure Paillère
Nees, Frauke
Orfanos, Dimitri Papadopoulos
Paus, Tomáš
Poustka, Luise
Fröhner, Juliane H.
Schmidt, Ulrike
Sinclair, Julia
Smolka, Michael N.
Stringaris, Argyris
Walter, Henrik
Whelan, Robert
Desrivières, Sylvane
Sahakian, Barbara J.
Robbins, Trevor W.
Schumann, Gunter
Jia, Tianye
Feng, Jianfeng
A shared neural basis underlying psychiatric comorbidity
title A shared neural basis underlying psychiatric comorbidity
title_full A shared neural basis underlying psychiatric comorbidity
title_fullStr A shared neural basis underlying psychiatric comorbidity
title_full_unstemmed A shared neural basis underlying psychiatric comorbidity
title_short A shared neural basis underlying psychiatric comorbidity
title_sort shared neural basis underlying psychiatric comorbidity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202801/
https://www.ncbi.nlm.nih.gov/pubmed/37095248
http://dx.doi.org/10.1038/s41591-023-02317-4
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