MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies,...

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Detalles Bibliográficos
Autores principales: Meyer zu Natrup, Christian, Schünemann, Lisa-Marie, Saletti, Giulietta, Clever, Sabrina, Herder, Vanessa, Joseph, Sunitha, Rodriguez, Marina, Wernery, Ulrich, Sutter, Gerd, Volz, Asisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202854/
https://www.ncbi.nlm.nih.gov/pubmed/37209676
http://dx.doi.org/10.3201/eid2906.230128
Descripción
Sumario:We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.

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