Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration

Human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. We present potent ME2 inhibitors based on cyro-EM structures that target ME2 enzyme activity. Two structures of ME2-inhibitor complexes demonstrate t...

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Detalles Bibliográficos
Autores principales: Hsieh, Ju-Yi, Chen, Kun-Chi, Wang, Chun-Hsiung, Liu, Guang-Yaw, Ye, Jie-An, Chou, Yu-Tung, Lin, Yi-Chun, Lyu, Cheng-Jhe, Chang, Rui-Ying, Liu, Yi-Liang, Li, Yen-Hsien, Lee, Mau-Rong, Ho, Meng-Chiao, Hung, Hui-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202922/
https://www.ncbi.nlm.nih.gov/pubmed/37217557
http://dx.doi.org/10.1038/s42003-023-04930-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202922/
https://www.ncbi.nlm.nih.gov/pubmed/37217557
http://dx.doi.org/10.1038/s42003-023-04930-y

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