AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

Cell migration is crucial for cancer dissemination. We find that AMP-activated protein kinase (AMPK) controls cell migration by acting as an adhesion sensing molecular hub. In 3-dimensional matrices, fast-migrating amoeboid cancer cells exert low adhesion/low traction linked to low ATP/AMP, leading...

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Detalles Bibliográficos
Autores principales: Crosas-Molist, Eva, Graziani, Vittoria, Maiques, Oscar, Pandya, Pahini, Monger, Joanne, Samain, Remi, George, Samantha L., Malik, Saba, Salise, Jerrine, Morales, Valle, Le Guennec, Adrien, Atkinson, R. Andrew, Marti, Rosa M., Matias-Guiu, Xavier, Charras, Guillaume, Conte, Maria R., Elosegui-Artola, Alberto, Holt, Mark, Sanz-Moreno, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202939/
https://www.ncbi.nlm.nih.gov/pubmed/37217519
http://dx.doi.org/10.1038/s41467-023-38292-0

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