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Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae

Stony coral tissue loss disease (SCTLD), one of the most pervasive and virulent coral diseases on record, affects over 22 species of reef-building coral and is decimating reefs throughout the Caribbean. To understand how different coral species and their algal symbionts (family Symbiodiniaceae) resp...

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Autores principales: Beavers, Kelsey M., Van Buren, Emily W., Rossin, Ashley M., Emery, Madison A., Veglia, Alex J., Karrick, Carly E., MacKnight, Nicholas J., Dimos, Bradford A., Meiling, Sonora S., Smith, Tyler B., Apprill, Amy, Muller, Erinn M., Holstein, Daniel M., Correa, Adrienne M. S., Brandt, Marilyn E., Mydlarz, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202950/
https://www.ncbi.nlm.nih.gov/pubmed/37217477
http://dx.doi.org/10.1038/s41467-023-38612-4
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author Beavers, Kelsey M.
Van Buren, Emily W.
Rossin, Ashley M.
Emery, Madison A.
Veglia, Alex J.
Karrick, Carly E.
MacKnight, Nicholas J.
Dimos, Bradford A.
Meiling, Sonora S.
Smith, Tyler B.
Apprill, Amy
Muller, Erinn M.
Holstein, Daniel M.
Correa, Adrienne M. S.
Brandt, Marilyn E.
Mydlarz, Laura D.
author_facet Beavers, Kelsey M.
Van Buren, Emily W.
Rossin, Ashley M.
Emery, Madison A.
Veglia, Alex J.
Karrick, Carly E.
MacKnight, Nicholas J.
Dimos, Bradford A.
Meiling, Sonora S.
Smith, Tyler B.
Apprill, Amy
Muller, Erinn M.
Holstein, Daniel M.
Correa, Adrienne M. S.
Brandt, Marilyn E.
Mydlarz, Laura D.
author_sort Beavers, Kelsey M.
collection PubMed
description Stony coral tissue loss disease (SCTLD), one of the most pervasive and virulent coral diseases on record, affects over 22 species of reef-building coral and is decimating reefs throughout the Caribbean. To understand how different coral species and their algal symbionts (family Symbiodiniaceae) respond to this disease, we examine the gene expression profiles of colonies of five species of coral from a SCTLD transmission experiment. The included species vary in their purported susceptibilities to SCTLD, and we use this to inform gene expression analyses of both the coral animal and their Symbiodiniaceae. We identify orthologous coral genes exhibiting lineage-specific differences in expression that correlate to disease susceptibility, as well as genes that are differentially expressed in all coral species in response to SCTLD infection. We find that SCTLD infection induces increased expression of rab7, an established marker of in situ degradation of dysfunctional Symbiodiniaceae, in all coral species accompanied by genus-level shifts in Symbiodiniaceae photosystem and metabolism gene expression. Overall, our results indicate that SCTLD infection induces symbiophagy across coral species and that the severity of disease is influenced by Symbiodiniaceae identity.
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spelling pubmed-102029502023-05-24 Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae Beavers, Kelsey M. Van Buren, Emily W. Rossin, Ashley M. Emery, Madison A. Veglia, Alex J. Karrick, Carly E. MacKnight, Nicholas J. Dimos, Bradford A. Meiling, Sonora S. Smith, Tyler B. Apprill, Amy Muller, Erinn M. Holstein, Daniel M. Correa, Adrienne M. S. Brandt, Marilyn E. Mydlarz, Laura D. Nat Commun Article Stony coral tissue loss disease (SCTLD), one of the most pervasive and virulent coral diseases on record, affects over 22 species of reef-building coral and is decimating reefs throughout the Caribbean. To understand how different coral species and their algal symbionts (family Symbiodiniaceae) respond to this disease, we examine the gene expression profiles of colonies of five species of coral from a SCTLD transmission experiment. The included species vary in their purported susceptibilities to SCTLD, and we use this to inform gene expression analyses of both the coral animal and their Symbiodiniaceae. We identify orthologous coral genes exhibiting lineage-specific differences in expression that correlate to disease susceptibility, as well as genes that are differentially expressed in all coral species in response to SCTLD infection. We find that SCTLD infection induces increased expression of rab7, an established marker of in situ degradation of dysfunctional Symbiodiniaceae, in all coral species accompanied by genus-level shifts in Symbiodiniaceae photosystem and metabolism gene expression. Overall, our results indicate that SCTLD infection induces symbiophagy across coral species and that the severity of disease is influenced by Symbiodiniaceae identity. Nature Publishing Group UK 2023-05-22 /pmc/articles/PMC10202950/ /pubmed/37217477 http://dx.doi.org/10.1038/s41467-023-38612-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Beavers, Kelsey M.
Van Buren, Emily W.
Rossin, Ashley M.
Emery, Madison A.
Veglia, Alex J.
Karrick, Carly E.
MacKnight, Nicholas J.
Dimos, Bradford A.
Meiling, Sonora S.
Smith, Tyler B.
Apprill, Amy
Muller, Erinn M.
Holstein, Daniel M.
Correa, Adrienne M. S.
Brandt, Marilyn E.
Mydlarz, Laura D.
Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title_full Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title_fullStr Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title_full_unstemmed Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title_short Stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional Symbiodiniaceae
title_sort stony coral tissue loss disease induces transcriptional signatures of in situ degradation of dysfunctional symbiodiniaceae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202950/
https://www.ncbi.nlm.nih.gov/pubmed/37217477
http://dx.doi.org/10.1038/s41467-023-38612-4
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