SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation

SMYD1, a striated muscle-specific lysine methyltransferase, was originally shown to play a key role in embryonic cardiac development but more recently we demonstrated that loss of Smyd1 in the murine adult heart leads to cardiac hypertrophy and failure. However, the effects of SMYD1 overexpression i...

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Detalles Bibliográficos
Autores principales: Szulik, Marta W., Valdez, Steven, Walsh, Maureen, Davis, Kathryn, Bia, Ryan, Horiuchi, Emilee, O’Very, Sean, Laxman, Anil K., Sandaklie-Nicolova, Linda, Eberhardt, David R., Durrant, Jessica R., Sheikh, Hanin, Hickenlooper, Samuel, Creed, Magnus, Brady, Cameron, Miller, Mickey, Wang, Li, Garcia-Llana, June, Tracy, Christopher, Drakos, Stavros G., Funai, Katsuhiko, Chaudhuri, Dipayan, Boudina, Sihem, Franklin, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Mitochondria at the Heart of Cardioprotection
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203008/
https://www.ncbi.nlm.nih.gov/pubmed/37212935
http://dx.doi.org/10.1007/s00395-023-00991-6

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