Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci

Alterations in the growth and maturation of chondrocytes can lead to variation in human height, including monogenic disorders of skeletal growth. We aimed to identify genes and pathways relevant to human growth by pairing human height genome-wide association studies (GWASs) with genome-wide knockout...

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Detalles Bibliográficos
Autores principales: Baronas, John M., Bartell, Eric, Eliasen, Anders, Doench, John G., Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Kronenberg, Henry M., Hirschhorn, Joel N., Renthal, Nora E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203046/
https://www.ncbi.nlm.nih.gov/pubmed/37228756
http://dx.doi.org/10.1016/j.xgen.2023.100299

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