Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison

BACKGROUND: Human insulin was the first FDA-approved biopharmaceutical drug produced through recombinant DNA technology. The previous studies successfully expressed recombinant human insulin precursors (HIP) in Pichia pastoris truncated and full-length α-factor recombinant clones. The matting α-fact...

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Detalles Bibliográficos
Autores principales: Utami, Nuruliawaty, Nurdiani, Dini, Hariyatun, Hariyatun, Putro, Eko Wahyu, Patria, Fadillah Putri, Kusharyoto, Wien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203085/
https://www.ncbi.nlm.nih.gov/pubmed/37212962
http://dx.doi.org/10.1186/s43141-023-00521-w

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