Cargando…
Repurposed inhibitor of bacterial dihydrodipicolinate reductase exhibits effective herbicidal activity
Herbicide resistance represents one of the biggest threats to our natural environment and agricultural sector. Thus, new herbicides are urgently needed to tackle the rise in herbicide-resistant weeds. Here, we employed a novel strategy to repurpose a ‘failed’ antibiotic into a new and target-specifi...
Autores principales: | Mackie, Emily R. R., Barrow, Andrew S., Giel, Marie-Claire, Hulett, Mark D., Gendall, Anthony R., Panjikar, Santosh, Soares da Costa, Tatiana P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203105/ https://www.ncbi.nlm.nih.gov/pubmed/37217566 http://dx.doi.org/10.1038/s42003-023-04895-y |
Ejemplares similares
-
A dual-target herbicidal inhibitor of lysine biosynthesis
por: Mackie, Emily RR, et al.
Publicado: (2022) -
Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants
por: Soares da Costa, Tatiana P, et al.
Publicado: (2021) -
Cloning, Expression, and Purification of Histidine-Tagged Escherichia coli Dihydrodipicolinate Reductase
por: Trigoso, Yvonne D., et al.
Publicado: (2016) -
Structural and Dynamic Requirements for Optimal Activity of the Essential Bacterial Enzyme Dihydrodipicolinate Synthase
por: Reboul, C. F., et al.
Publicado: (2012) -
Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor
por: Lee, Chang Woo, et al.
Publicado: (2018)