Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in embryogenesis remains unknown. Here, we establish a system of simultaneous inactivation of m...

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Detalles Bibliográficos
Autores principales: Li, Qing, Lu, Jiansen, Yin, Xidi, Chang, Yunjian, Wang, Chao, Yan, Meng, Feng, Li, Cheng, Yanbo, Gao, Yun, Xu, Beiying, Zhang, Yao, Wang, Yingyi, Cui, Guizhong, Xu, Luang, Sun, Yidi, Zeng, Rong, Li, Yixue, Jing, Naihe, Xu, Guo-Liang, Wu, Ligang, Tang, Fuchou, Li, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203112/
https://www.ncbi.nlm.nih.gov/pubmed/37217538
http://dx.doi.org/10.1038/s41467-023-38528-z

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