Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation

Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The deficiency of ZMPSTE24 could induce Hutchinson–Gilford progeria syndrome (HGPS), a genetic diso...

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Detalles Bibliográficos
Autores principales: Suo, Jinlong, Shao, Rui, Yang, Ruici, Wang, Jinghui, Zhang, Zhong, Wang, Duo, Niu, Ningning, Zheng, Xianyou, Zou, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203117/
https://www.ncbi.nlm.nih.gov/pubmed/37217512
http://dx.doi.org/10.1038/s41419-023-05856-3

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