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Latest updates on the serotonergic system in depression and anxiety

Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic with complicated etiologies. Current drug-based therapies incl...

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Autores principales: Lin, Jianwen, Liu, Wenxin, Guan, Jing, Cui, Jianing, Shi, Ruolin, Wang, Lu, Chen, Dong, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203201/
https://www.ncbi.nlm.nih.gov/pubmed/37228487
http://dx.doi.org/10.3389/fnsyn.2023.1124112
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author Lin, Jianwen
Liu, Wenxin
Guan, Jing
Cui, Jianing
Shi, Ruolin
Wang, Lu
Chen, Dong
Liu, Yi
author_facet Lin, Jianwen
Liu, Wenxin
Guan, Jing
Cui, Jianing
Shi, Ruolin
Wang, Lu
Chen, Dong
Liu, Yi
author_sort Lin, Jianwen
collection PubMed
description Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic with complicated etiologies. Current drug-based therapies include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, and 5-hydroxytryptamine partial agonists. However, these modalities share common limitations, such as slow onset and low efficacy, which is why potential mechanistic insights for new drug targets are needed. In this review, we summarize recent advances in brain localization, pathology, and therapeutic mechanisms of the serotonergic system in depression and anxiety.
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spelling pubmed-102032012023-05-24 Latest updates on the serotonergic system in depression and anxiety Lin, Jianwen Liu, Wenxin Guan, Jing Cui, Jianing Shi, Ruolin Wang, Lu Chen, Dong Liu, Yi Front Synaptic Neurosci Neuroscience Psychiatric disorders are among the leading causes of global health burden, with depression and anxiety being the most disabling subtypes. The two common disorders, depression and anxiety, usually coexist and are pathologically polygenic with complicated etiologies. Current drug-based therapies include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, and 5-hydroxytryptamine partial agonists. However, these modalities share common limitations, such as slow onset and low efficacy, which is why potential mechanistic insights for new drug targets are needed. In this review, we summarize recent advances in brain localization, pathology, and therapeutic mechanisms of the serotonergic system in depression and anxiety. Frontiers Media S.A. 2023-05-09 /pmc/articles/PMC10203201/ /pubmed/37228487 http://dx.doi.org/10.3389/fnsyn.2023.1124112 Text en Copyright © 2023 Lin, Liu, Guan, Cui, Shi, Wang, Chen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lin, Jianwen
Liu, Wenxin
Guan, Jing
Cui, Jianing
Shi, Ruolin
Wang, Lu
Chen, Dong
Liu, Yi
Latest updates on the serotonergic system in depression and anxiety
title Latest updates on the serotonergic system in depression and anxiety
title_full Latest updates on the serotonergic system in depression and anxiety
title_fullStr Latest updates on the serotonergic system in depression and anxiety
title_full_unstemmed Latest updates on the serotonergic system in depression and anxiety
title_short Latest updates on the serotonergic system in depression and anxiety
title_sort latest updates on the serotonergic system in depression and anxiety
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203201/
https://www.ncbi.nlm.nih.gov/pubmed/37228487
http://dx.doi.org/10.3389/fnsyn.2023.1124112
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